2012 Fiscal Year Final Research Report
Tailor-made bone regeneration as a pre-prosthodontic treatment based on the concept of tissue engineering triad
| Project/Area Number |
23659902
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOYANO Kiyoshi 九州大学, 大学院・歯学研究院, 教授 (50195872)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨再生 / テーラーメイド医療 / ティッシュエンジニアリング / 補綴前処置 |
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| Research Abstract |
According to the principle of tissue engineering triad, cells, bioactive molecules, and scaffold are thought to be essential for regeneration. From this point, it is supposed that not every site expected to augment bone tissue requires same element.From the results of our experiments, the local application of both osteoblast-differentiation factor and osteoblast-proliferation factor could induce bone formation. But the bone induced by the former represented more mineralized bone than that induced by the latter. In addition, osteoblast-differentiation factor stimulated the Smad-signaling pathway in the osteoblast-like cells.
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