2012 Fiscal Year Final Research Report
Isolation of mesenchymal stem cells for induction of dental hard tissue from rat gingiva.
| Project/Area Number |
23659908
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
IIZUKA Tadashi 北海道大学, 大学院・歯学研究科, 准教授 (80168062)
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| Co-Investigator(Kenkyū-buntansha) |
TAKITA Hiroko 北海道大学, 大学院・歯学研究科, 助教 (30125330)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Tomomi 北海道大学, 大学院・歯学研究科, 技術専門職員 (50399953)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 再生歯学 / 歯肉 / 間葉系幹細胞 |
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| Research Abstract |
The purpose of this study was examined the localization of mesenchymal stem cells in the gingiva and evaluated multilineage differentiation capacity of these cells. As a result, we demonstrated the presence of cells positive for the mesenchymal stem cell marker STRO-1 in the rat gingival tisuue. These STRO-1 positive cells also indicated osteogenic differentiation. In this study, it was thought that gigival stem cells has a possibility for induction of dental hard tissue.
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