2012 Fiscal Year Final Research Report
Enhancement of bone health in rat mandible by application of mechanical stimulation using a mouthpiece-like vibrator
| Project/Area Number |
23659920
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KURATA Kosaku 九州大学, 工学研究院, 機械工学部門 (00368870)
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| Co-Investigator(Renkei-kenkyūsha) |
AYUKAWA Yasunori 九州大学, 大学病院, 講師 (50304697)
MORIYAMA Yasuko 九州大学, 大学院・歯学研究院, 助教 (50452769)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯学 / 生物・生体工学 / 再生医学 / 微小振動 / 骨リモデリング |
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| Research Abstract |
The aim of this study was to develop a new method to enhance the strength of mandibles by an application of low-magnitude, high-frequency mechanical vibration through a mouthpiece-type vibrator. Although rat incisors were fixed to the mouthpiece and exposed to the vibration, the resonance point, which was expected to maximize the effect of the vibration, was not observed. However, the vibration with amplitudes of several tens to hundreds microns at several tens of hertz could enhance mass transport in rat mandibles, NO secretion from osteocytes in vitro, and bone healing of rat incisor extraction sockets.
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[Journal Article] Evidence for osteocyte regulation of bone homeostasis through RANKL expression2011
Author(s)
Tomoki Nakashima, Mikihito Hayashi, Takanobu Fukunaga, Kosaku Kurata, Masatsugu Oh-hora, Jian Q Feng, Lynda F Bonewald, Tatsuhiko Kodama, Anton Wutz, Erwin F Wagner, Josef M Penninger, Hiroshi Takayanagi
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Journal Title
Nature Medicine
Volume: Vol.17
Pages: 1231-1234
Peer Reviewed
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