2012 Fiscal Year Final Research Report
We elucidated osteogenic capacity of CD90-posidive cells and side population (SP) cells derived from bone marrow stromal cells to establish the hard tissue regeneration therapy. Most of bone marrow stromal cells expressed CD90, one of mesenchymal stem cell markers, and contained 0.5% SP cells. CD90-positive cells and SP cells could differentiate osteoblastic cells in in vitro and in vivo. However, we could not clarify specific genes of osteoprogenitor cells.
| Project/Area Number |
23659926
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Dental engineering/Regenerative dentistry
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HOSOYA Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
YUKITA Akira 松本歯科大学, 歯学部, 助教 (80401214)
NINOMIYA Tadashi 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨原性細胞 / 骨髄間葉系細胞 / CD90 / Side population |
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| Research Abstract |
We elucidated osteogenic capacity of CD90-posidive cells and side population (SP) cells derived from bone marrow stromal cells to establish the hard tissue regeneration therapy. Most of bone marrow stromal cells expressed CD90, one of mesenchymal stem cell markers, and contained 0.5% SP cells. CD90-positive cells and SP cells could differentiate osteoblastic cells in in vitro and in vivo. However, we could not clarify specific genes of osteoprogenitor cells.
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Research Products
(2 results)
