2012 Fiscal Year Final Research Report
Diagnosis by microRNA in blood and saliva, and development of the new treatment method to oral cancer
| Project/Area Number |
23659934
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | University of Tsukuba |
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Principal Investigator |
BUKAWA Hiroki 筑波大学, 医学医療系, 教授 (80173558)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口腔がん / micro RNA / 血液 / 唾液 / let-7 family |
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| Research Abstract |
Microarrays have been applied to determine the expression patterns of about 100 kinds of microRNA in the oral cancer derived cell lines, primary oral cancer tissues, blood and saliva. We have demonstrated that let-7 family was down-regulated in oral cancer derived cell lines and primary oral cancer tissues. We found the relationship to the characteristics of the expression in blood, salivaand tissue in oral cancer. In addition, we also observed microRNAs expression showing commonchanges in those.
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