2013 Fiscal Year Final Research Report
Cell destruction and reloading treatment for bone graft in oral cancer surgery
| Project/Area Number |
23659942
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Nagoya University |
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Principal Investigator |
HIBI Hideharu 名古屋大学, 医学(系)研究科(研究院), 准教授 (90345885)
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| Co-Investigator(Kenkyū-buntansha) |
UEDA Minoru 名古屋大学, 医学系研究科, 教授 (00151803)
YAMAMOTO Akihito 名古屋大学, 医学系研究科, 准教授 (50244083)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 再生医学 / 細胞・組織 / 移植・再生医療 |
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| Research Abstract |
The aim of the study is to improve graft survival rate of the bone fragment freeze-treated with liquid nitrogen for oral cancer surgery. Bone marrow stromal cells, their conditioned media and phosphate buffered saline were applied to the freeze-treated bone fragments of the rat mandibles. The bone fragments were reimplanted and then observed histologically 2 and 4 weeks after surgery. Histologic specimens showed the number of the live cells within the bone unit areas in the bone fragments applied with the media was larger than those with phosphate buffered saline or the cells. The media were effective to improve the graft survival rate of the freeze-treated bone.
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Research Products
(29 results)
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[Journal Article] Rat bone marrow stromal cell-conditioned medium promotes early osseointegration of titanium implants2013
Author(s)
Tsuchiya, S., Hara, K., lkeno, M., Okamoto, Y., Hibi, H., Ueda, M
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Journal Title
International Journal of Oral & Maxillofacial Implants
Volume: 28(5)
Pages: 1360-1369
DOI
Peer Reviewed
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[Journal Article] Novel application of stem cell-derived factors for periodontal regeneration2013
Author(s)
Inukai, T., Katagiri, W., Yoshimi, R., Osugi, M.,Kawai, T., Hibi, H., Ueda, M
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Journal Title
Biochemical and Biophysical Research Communications
Volume: 430(2)
Pages: 763-768
DOI
Peer Reviewed
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[Journal Article] Mesenchymal stromal cells of human umbilical cord Wharton's jelly accelerate wound healing by paracrine mechanisms2012
Author(s)
Shohara, R.,Yamamoto, A.,Takikawa, S., Iwase, A., Hibi, H., Kikkawa, F., Ueda, M
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Journal Title
Cytotherapy
Volume: 14(10)
Pages: 1171-1181
DOI
Peer Reviewed
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[Journal Article] Conditioned media from mesenchymal stem cells enhanced bone regeneration in rat calvarial bone defects2012
Author(s)
Osugi, M.,Katagiri, W.,Yoshimi, R., Inukai, T., Hibi, H., Ueda, M
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Journal Title
Tissue Engineering Part A
Volume: 18(13-14)
Pages: 1479-1489
DOI
Peer Reviewed
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