2012 Fiscal Year Final Research Report
Boron neutron capture therapy in combination with sonoporation
| Project/Area Number |
23659944
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YURA Yoshiaki 大阪大学, 大学院・歯学研究科, 教授 (00136277)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口腔扁平上皮癌 / 中性子 / ホウ素化合物 / 超音波照射 / マイクロバブル |
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| Research Abstract |
Boron neutron capture therapy (BNCT) is a selective radiotherapy, using 10B compounds such as boronophenylalanine (BPA) and boronocaptate sodium (BSH). Sonoporation that enables extracellular materials to enter into cells was used to increase intratumoral 10B concentration. In oral squamous cell carcinoma (SCC) cells and tumors in nude mice, the 10B concentration was increased by sonoporation and tumor growth was suppressed remarkably. This suggests that sonoporation enhances the efficiency of BPA-mediated BNCT for oral SCC.
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