2013 Fiscal Year Final Research Report
Study of the delivery system of nucleic acid medicines targeting cell adhesion molecules controlling the metastasis of oral cancer
| Project/Area Number |
23659945
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Hiroshima University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
OKAMOTO Tetsuji 広島大学, 医歯薬保健学研究院, 教授 (00169153)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Keywords | 口腔癌 / 細胞接着 / インテグリン / 浸潤 / 転移 |
|---|
| Research Abstract |
Transfection of squamous cell carcinoma (SCC) cells with a mammalian expression vector containing the cDNA for integrin alpha V in the antisense orientation reduced alpha V expression in SCC cells. Transfection with antisense oligonucleotides targeting integrin beta 8 reduced beta 8 expression in SCC cells. Suppression of integrin alpha V or beta 8 by transfection with antisense cDNA plasmid or antisense oligonucleotides led to a decrease in the proliferation and invasiveness of SCC cells. In addition, the downregulation of integrin alpha V or beta8 significantly reduced the tumorigenicity of oral SCC.
|
