2012 Fiscal Year Final Research Report
Expression and function of secreted microRNAs in oral cancer
| Project/Area Number |
23659947
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Surgical dentistry
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| Research Institution | Ehime University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAKASHIRO Koichi 愛媛大学, 大学院・医学系研究科, 准教授 (90314880)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 口腔癌 / microRNA / エクソソーム |
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| Research Abstract |
In this study, we attempted to explore specific microRNAs (miRNAs) in serum and saliva derived from patients with oral cancer. Specifically 17 increased miRNAs and 15 undetectable miRNAs in serum from oral cancer patients were commonly identified. Among these miRNAs, hsa-miR-181b was markedly elevated in not only serum but also saliva from oral cancer patients. These miRNAs may be useful for detection of oral cancer.
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[Journal Article] Prognostic impact of expression of bcl-2 and bax genes in circulating immune cells derived from patients with head and neck carcinoma2013
Author(s)
Tano T, Okamoto M, Kan S, Nakashiro K, Shimodaira S, Koido S, Homma S, Sato M,Fujita T, Kawakami Y, Hamakawa H
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Journal Title
Neoplasia
Volume: 15(3)
Pages: 305-14
Peer Reviewed
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