2012 Fiscal Year Final Research Report
A study on mevalonic acid pathway-targeting therapy to recovery osteoclasts damaged with bisphosphonate
| Project/Area Number |
23659957
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Surgical dentistry
|
|---|
| Research Institution | Fukuoka Dental College |
|---|
Principal Investigator |
IKEBE Tetsuro 福岡歯科大学, 口腔歯学部, 教授 (20202913)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 破骨細胞 / 顎骨壊死 / ビスフォスフォネート / メバロン酸 |
|---|
| Research Abstract |
Nitrogen-containing bisphosphonate (BP) is used as effective therapeutic agent for managing bone-resorbing diseases such as osteoporosis and cancer bone metastasis. It is well know n that osteonecrosis of the jaw occasionally occurs in the patients treated with nitrogen-containing bisphosphonate after tooth extraction, which is called as BRONJ. Although BRONJ is quite difficult to treat and annoys both the patients and dentists for a long time, any effective therapies for BRONJ have not been established. The target cell of BP is osteoclast. BP inhibits the mevalonic acid pathway of osteoclast to inhibit osteoclastic bone-resorbing activity. In order to recover the BP-induced inhibition of osteoclast activity, the effects of geranylgeraniol (GGOH), an intermediate of mevalonic acid pathway, on BP-induced inhibition of osteoclast activity was investigated in this study. As a result, the addition of GGOH to cultured osteoclasts restored multinucleation, TRAP expression, cell migratinability and the expression of cell fusion-promoting factor STAMP of BP-inhibited osteoclasts. This study suggests that GGOH may neutralize the adverse effects of BP in osteoclasts.
|
Research Products
(2 results)
