2012 Fiscal Year Final Research Report
Outbreaktal study to development the cytologic therapy to restore the elder persons to be young with milk tooth
| Project/Area Number |
23659967
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontic/Pediatric dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZA Haruyoshi 九州大学, 歯学研究院, 講師 (30336151)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 小児歯科学 / 乳歯 / 幹細胞 |
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| Research Abstract |
We isolated mesenchymal stem cells from human exfoliated deciduous teeth (SHED). SHED owned stem cell properties including clonogenicity, self-renew, stem cell marker expression, multipotency, in vivo tissue regenerative capacity and in vitro immunomodulatory function. To examine the therapeutic efficacy of SHED on immune diseases, SHED were intravenously transplanted into systemic lupus erythematosus (SLE) model MRL/lpr mice. Systemic SHED transplantation improved SLE-like disorders including short lifespan, elevated autoantibody levels and nephritis-like renal dysfunction. SHED transplantation was also able to recover osteoporosis bone reduction in long bones of MRL/lpr mice. Furthermore, SHED -mediated tissue engineering induced bone regeneration in critical calvarial bone-defect sites of immunocompromised mice. These data suggest SHED is source of the stem cell-based immune therapy and tissue engineering in regenerative medicine
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[Journal Article] Protein instability and functional defects caused by mutations of dihydro-orotate dehydrogenase in Miller syndrome patients2012
Author(s)
JingXian Fang, Takeshi Uchiumi, Mikako Yagi, Shinya Matsumoto, Rie Amamoto, Toshiro Saito, Shinya Takazaki, Tomotake Kanki, Haruyoshi Yamaza, Kazuaki Nonaka, Dongchon Kang
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Journal Title
BIOSCIENCE REPORTS
Volume: 32
Pages: 631-639
Peer Reviewed
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[Journal Article] The primary site of the acrocephalic feature in Apert Syndrome is a dwarf cranial base with accelerated chondrocytic differentiation due to aberrant activation of the FGFR2 signaling2010
Author(s)
Nagata M, Nuckolls GH, Wang X, Shum L, Seki Y, Kawase T, Takahashi K, Nonaka K, Takahashi I, Noman AA, Suzuki K, Slavkin HC
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Journal Title
Bone
Volume: 48(4)
Pages: 847-56
DOI
Peer Reviewed
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[Presentation] Long Term Cryopreserved Dental Pulp Tissues of Exfoliated Deciduous Teeth Utilize for a Feasible Stem Cell Resource for Regenerative Medicine2012
Author(s)
Lan Ma, Haruyoshi Yamaza, Kentaro Akiyama, Guangtai Song, Toshio Kukita, Songtao Shi, Kazuaki Nonaka, Takayoshi Yamaza
Organizer
Gordon Research Conference, Musculoskeletal Biology & Bioengineering
Place of Presentation
Andover, NH, USA
Year and Date
2012-08-08
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[Presentation] Mitochondria is involved in Miller Syndrome2012
Author(s)
Jingxian Fang, Takeshi Uchiumi, Mikako Yagi, Haruyoshi Yamaza, Dongchon Kang, Kazuaki Nonaka
Organizer
Gordon Research Conference: Craniofacial Morphogenesis & Tissue Regeneration
Place of Presentation
Ventura, CA, USA
Year and Date
2012-03-17
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