2012 Fiscal Year Final Research Report
Establishment of the new concept "pathogenic mechanism of periodontal disease by the induction of senescence of the tissues".
| Project/Area Number |
23659974
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Periodontal dentistry
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HONDA Tomoyuki 新潟大学, 医歯学総合病院, 医員 (30447635)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯周免疫機能学 |
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| Research Abstract |
Endoplasmic reticulum stress was induced in gingival tissue of orally periodontopathic bacterium infected mice. Administration of chemical chaperone,4-phenylbutyric acid, significantly inhibited alveolar bone resorption in the infected mice. In addition, 4-phenylbutyric acid inhibited osteoclastogenesis in vitro. Our findings suggest that endoplasmic reticulum stress involves osteoclastogenesis during alveolar bone resorption in the progression of periodontal disease.
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