2012 Fiscal Year Final Research Report

Passive smoking-induced epigenetic regulation in tooth・periodontal tissue-associated genes.

Research Project

Project/Area Number	23659975
Research Category	Grant-in-Aid for Challenging Exploratory Research
Allocation Type	Multi-year Fund
Research Field	Periodontal dentistry
Research Institution	Osaka University
Principal Investigator	KITAMURA Masahiro 大阪大学, 大学院・歯学研究科, 准教授 (10243247)
Co-Investigator(Kenkyū-buntansha)	YANAGITA Manabu 大阪大学, 大学院・歯学研究科, 助教 (80379081) YAMASHITA Motozo 大阪大学, 歯学部附属病院, 助教 (90524984)
Project Period (FY)	2011 – 2012
Keywords	喫煙 / 歯周病
Research Abstract	In this study, we established the mouse model of experimental periodontitis similar to human periodontal lesion and investigated the effects of cigarette smoke constituents for pathogenesis of periodontal diseases using this model. In result, we found that intraperitoneally administration of nicotine or cigarette smoke condensate accelerated alveolar bone loss in mice compared with control group. These results indicate the useful animal model to examine the effects of smoking for oral diseases in human.