2012 Fiscal Year Final Research Report
Search for oral predominant bacteria and clarification of causative components which affect growth and virulence factors of periodontopathic bacteria
| Project/Area Number |
23659984
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Social dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
NAGATA Hideki 大阪大学, 歯学研究科(研究院), 准教授 (50260641)
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| Co-Investigator(Kenkyū-buntansha) |
OJIMA Miki 大阪大学, 歯学研究科(研究院), 助教 (20263303)
MAEDA Kazuhiko 大阪大学, 歯学研究科(研究院), 助教 (00346165)
TANAKA Muneo 大阪大学, 歯学部附属病院, 講師 (90263300)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 歯周病細菌 / 口腔常在菌 / 病原因子 / バイオフィルム |
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| Research Abstract |
Interaction with oral predominant bacteria plays an important role in colonization of periodontopathic bacteria. Culture supernatant of Streptococcus oralis repressed growth of Porphyromonas gingivalis. S. oralisglyceraldehydes-3-phosphate dehydrogenase (GAPDH), which binds P. gingivalisfimbriae, affected expression of P. gingivalis gene related to biofilm formation.
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