2013 Fiscal Year Final Research Report
Molecular and cellular mechanisms of DCX family proteins in brain development
| Project/Area Number |
23680035
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Neuroscience in general
|
|---|
| Research Institution | Osaka Bioscience Institute |
|---|
Principal Investigator |
KOIZUMI Hiroyuki 公益財団法人大阪バイオサイエンス研究所, 神経細胞生物学部門, 研究員 (10334335)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 軸索伸長 / 神経細胞移動 |
|---|
| Research Abstract |
Doublecortin (Dcx) and Doublecortin-like kinases (Dclk1, Dclk2) function cooperatively in cortical layer formation and axon and dendrite formation that is required for the proper neural circuit formation. DCX family proteins deficiency is associated with epilepsy.
In this project, we identified a novel target of DCLK1, MAP7D1. Depletion of MAP7D1 in cortical layer 2/3 pyramidal cells resulted in impaired axon elongation in the corpus callosum. Overexpression of unphosphorylated mutant MAP7D1, but not wild-type MAP7D1, also impaired callosal axon elongation. These results suggested that phosphorylation of MAP7D1 by DCLK1 regulate axon elongation in neurons.
|
Research Products
(7 results)
-
[Journal Article]2013
Author(s)
Shin, E., Kashiwagi, Y., Kuriu, T., Iwasaki, H., Tanaka, T., Koizumi, H., Gleeson, J.G., & Okabe, S.
-
Journal Title
Nat. Commun
Volume: 4
Pages: 1440
Peer Reviewed
-
-
-
-
-
-
