Draxin roles in thalamocortical projections.

2013 Fiscal Year Final Research Report

• Project/Area Number: 23680036
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kumamoto University
• Principal Investigator: SHINMYO Yohei 熊本大学, 大学院生命科学研究部(医), 助教 (00418831)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: 軸索ガイダンス / 視床皮質軸索投射

Research Abstract

In this study, we have focused on Draxin functions in thalamocortical projections. It has long been recognized that neocortical pioneer axons from subplate neurons are essential for the guidance of thalamocortical projections. Draxin is strongly expressed in early-born cortical neurons, including subplate and Cajal-Retzius cells, and weakly expressed in the ventral telencephalon and dorsal thalamus. Draxin deficient mice showed severe defects in thalamocortical projections. Thalamic axons showed a pathfinding error in the internal capsule region at embryonic day 14.5, when cortical axon pathfinding still appeared normal.
This suggests that draxin has direct functions in thalamocortical projections. Furthermore, the thalamocortical phenotype in draxin-/- mice is sufficiently rescued by transgenic expression of draxin in the neocortex. These results suggest that draxin from neocortical pioneer neurons is required for the guidance of thalamocortical projections.

Research Products

• [Journal Article] The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation (2013)
  • Author(s): Hossain M, Ahmed G, Naser IB, Shinmyo Y, Ito A, Riyadh MA, Felemban A, Song X, Ohta K and Tanaka H
  • Journal Title: Dev. Biol. Volume: 374 Pages: 58-70
  • Peer Reviewed
• [Journal Article] 神経回路形成における軸索ガイダンス分子draxinの役割 (2013)
  • Author(s): 新明洋平
  • Journal Title: 生化学ミニレビュー Volume: Vol.85 No.9
  • Peer Reviewed
• [Presentation] 大脳新皮質に発現するdraxinが視床皮質軸索投射に必須である (2013)
  • Author(s): Shinmyo Y., Riyadh A, Hossain M, Ahmed G, Naser IB, Song X, Ito A, Takebayashi H, Ohta K and Tanaka H
  • Organizer: 第36回日本分子生物学会年会
  • Place of Presentation: 神戸市,神戸国際会議場
  • Year and Date: 20131203-06
• [Presentation] Draxin from neocortical neurons controls thalamocortical projections into the neocortex (2013)
  • Author(s): Shinmyo Y., Riyadh A, Hossain M, Ahmed G, Naser IB, Song X, Ito A, Takebayashi H, Ohta K and Tanaka H
  • Organizer: Neuroscience 2013
  • Place of Presentation: Sandiego, USA.Sandiego Convention Center
  • Year and Date: 20131109-13
• [Presentation] 大脳新皮質に発現するdraxinが視床皮質軸索投射に必須である (2013)
  • Author(s): 新明洋平
  • Organizer: 第118回日本解剖学会
  • Place of Presentation: 高松,かがわ国際会議場
  • Year and Date: 20130328-30
• [Presentation] Draxin from neocortical neurons controls thalamocortical projections into the neocortex (2012)
  • Author(s): Shinmyo Y., Riyadh A, Hossain M, Ahmed G, Naser IB, Song X, Ito A, Takebayashi H, Ohta K and Tanaka H
  • Organizer: Neuroscience 2012
  • Place of Presentation: New Orleans, USA. , Ernest N.Morial Convention Center
  • Year and Date: 20121013-17
• [Presentation] Draxin from neocortical neurons controls thalamocortical projections into the neocortex. U.S.-Japan Brain Research Cooperative Program (2012)
  • Author(s): Shinmyo Y.
  • Organizer: Growth Cones & Axon Regeneration
  • Place of Presentation: New Orleans, USA.The University of Taxas
  • Year and Date: 20121010-12
• [Presentation] Draxin from neocortical neurons controls thalamocortical projections into the neocortex. Gordon Research Conferences (2012)
  • Author(s): Shinmyo Y., Riyadh A, Hossain M, Ahmed G, Naser IB, Song X, Ito A, Takebayashi H, Ohta K and Tanaka H
  • Organizer: Newport RI
  • Place of Presentation: USA.Salve Regina University
  • Year and Date: 20120812-17
• [Presentation] Draxin from neocortical neurons controls thalamocortical projections into the neocortex (2012)
  • Author(s): Shinmyo Y., Riyadh A, Hossain M, Ahmed G, Naser IB, Song X, Ito A, Takebayashi H, Ohta K and Tanaka H
  • Organizer: 日本発生生物学会題45回大会
  • Place of Presentation: 神戸市,神戸国際会議場
  • Year and Date: 20120528-31
• [Presentation] draxin has a unique role for the guidance of thalamocortical projections (2011)
  • Author(s): Shinmyo Y., Riyadh A., Hossain M., Ahmed G., Naser I.B., Song X., Ito A., Takebayashi H., Ohta K. and Tanaka H
  • Organizer: Neuroscience 2011
  • Place of Presentation: Washington DC, USA.Washington Convention Center
  • Year and Date: 20111112-16
• [Presentation] draxin has a unique role for the guidance of thalamocortical projections (2011)
  • Author(s): Shinmyo Y., Riyadh A., Hossain M., Ahmed G., Naser I.B., Song X., Ito A., Takebayashi H., Ohta K. and Tanaka H
  • Organizer: Assembly, Plasticity, Dysfunction and Repair of Neural Circuits
  • Place of Presentation: Cold Spring Harbor Asia, Suzhou, China.Suzhou Dushu Lake Conference Center
  • Year and Date: 20111017-21
• [Presentation] draxin has a unique role for the guidance of thalamocortical projections (2011)
  • Author(s): Shinmyo Y., Riyadh A., Hossain M., Ahmed G., Naser I.B., Song X., Ito A., Takebayashi H., Ohta K. and Tanaka H
  • Organizer: The 34^<nd> Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: 横浜市,パシフィッコ横浜
  • Year and Date: 20110914-17
• [Book] 大脳新皮質での神経回路の形成における軸索ガイダンス機構 (2014)
  • Author(s): 新明洋平、田中英明
  • Total Pages: e002
  • Publisher: 領域融合レビュー3(DOI : 10.7875/leading.author.3.e002)
• [Book] 脳の発生学ニューロンの誕生・分化・回路形成 (7章"軸索投射のガイダンス、トポグラフィックマップ形成"分担執筆) (2013)
  • Author(s): 宮田卓樹、山本亘彦編
  • Total Pages: 07
  • Publisher: DOJIN BIOSCIENCE SERIES