2013 Fiscal Year Final Research Report
Developmental dynamics of mouse olfactory circuits
| Project/Area Number |
23680038
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
IMAI TAKESHI 独立行政法人理化学研究所, 発生・再生科学総合研究センター, チームリーダー (70509851)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Keywords | 樹状突起 / 刈り込み / 嗅球 / 僧帽細胞 / 嗅覚 |
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| Research Abstract |
In the mouse olfactory bulb, inputs from olfactory sensory neurons are relayed to second-order neurons, mitral and tufted cells. A mitral/tufted cell extends a single primary dendrite toward a glomerulus, as well as several lateral dendrites. A mitral/tufted cell initially extends multiple dendrites to glomeruli, but they prune all but one dendrite and thereby establish a single primary dendrite during the first postnatal week. In this study, we established a method for quantitative analyses of mitral cell dendrites. We also found that neuronal activity plays an important role in the dendrite pruning process.
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[Journal Article] Agonist-Independent GPCR Activity Regulates Anterior-Posterior Targeting of Olfactory Sensory Neurons2013
Author(s)
Nakashima A, Takeuchi H, Imai T, Saito H, Kiyonari H, Abe T, Chen M, Weinstein LS, Ron Yu C, Storm DR, Nishizumi H, Sakano H
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Journal Title
Cell
Volume: 154
Pages: 1314-1325
DOI
Peer Reviewed
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