Cognitive neuroscience of moral and judicial judgments

2013 Fiscal Year Final Research Report

• Project/Area Number: 23680045
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Fusional social brain science
• Research Institution: Kyoto University
• Principal Investigator: TAKAHASHI Hidehiko 京都大学, 医学(系)研究科(研究院), 准教授 (60415429)
• Project Period (FY): 2011-11-18 – 2014-03-31
• Keywords: 道徳 / 司法 / 意思決定 / 認知神経科学 / 精神医学

Research Abstract

Using neuroimaging methods, we investigated neurocognitive mechanisms of judicial and moral judgments, and the role s of sympathy, fairness, impulsivity and social cognition on them in healthy volunteers and neuropsychiatric disorders.
Legal punitive judgments (criminal sentences) activated precuneus and anterior cingulate cortex, suggesting that sentencing is based on negative affective responses to murder, sympathy for mitigating circumstances and cognitive control to choose numerical punishments. Individual differences on the inclination to mitigate correlated with activity in the insula. We found that individuals with a low level of serotonin transporters in the midbrain including dorsal raphe nucleus are honest and trustful, and thus cannot tolerate unfairness, being candid in expressing their frustrations.

Research Products

• [Journal Article] Can we predict burnout severity from empathy-related brain activity? (2014)
  • Author(s): Tei S, Becker C, Kawada R, Fujino J, Jankowski K, Sugihara G, Murai T, Takahashi H
  • Journal Title: Transl Psychiatry Volume: (in press
  • Peer Reviewed
• [Journal Article] Cognitive neuroscience of social emotions and implications for psychopathology : Examining embarrassment, guilt, envy, and schadenfreude (2014)
  • Author(s): Jankowski KF, Takahashi H
  • Journal Title: Psychiatry Clin Neurosci Volume: 68(5) Pages: 319-36
  • Peer Reviewed
• [Journal Article] Impaired empathic abilities and reduced white matter integrity in schizophrenia (2014)
  • Author(s): Fujino J, Takahashi H, Miyata J, Sugihara G, Kubota M, Sasamoto A, Fujiwara H, Aso T, Fukuyama H, Murai T
  • Journal Title: Prog Neuropsychopharmacol Biol Psychiatry Volume: 8 Pages: 117-23
  • Peer Reviewed
• [Journal Article] Cerebral Responses to Vocal Attractiveness and Auditory Hallucinations in Schizophrenia : A Functional MRI Study (2013)
  • Author(s): Koeda M, Takahashi H, Matsuura M, Asai K, Okubo Y
  • Journal Title: Front Hum Neurosci Volume: 7 Pages: 221
  • Peer Reviewed
• [Journal Article] Impact of gray matter reductions on theory of mind abilities in patients with schizophrenia (2013)
  • Author(s): Koelkebeck K, Hirao K, Miyata J, Kawada R, Saze T, Dannlowski U, Ubukata S, Ohrmann P, Bauer J, Pedersen A, Fukuyama H, Sawamoto N, Takahashi H, Murai T
  • Journal Title: Soc Neurosci Volume: 8(6) Pages: 631-9
  • Peer Reviewed
• [Journal Article] PET neuroimaging of extrastriatal dopamine receptors and prefrontal cortex functions (2013)
  • Author(s): Takahashi H
  • Journal Title: J Physiol Paris Volume: 107(6) Pages: 503-9
  • Peer Reviewed
• [Journal Article] Noninvasive remote activation of the ventral midbrain by transcranial direct current stimulation of prefrontal cortex (2013)
  • Author(s): Chib V, Yun K, Takahashi H, Shimojo S
  • Journal Title: Transl Psychiatry Volume: 3 Pages: e266
  • Peer Reviewed
• [Journal Article] Regional gray matter reduction correlates with subjective quality of life in schizophrenia (2013)
  • Author(s): Ubukata S, Miyata J, Yoshizumi M, Uwatoko T, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: J Psychiatr Res Volume: 47(4) Pages: 548-54
  • Peer Reviewed
• [Journal Article] Global association between cortical thinning and white matter integrity reduction in schizophrenia (2013)
  • Author(s): Sasamoto A, Miyata J, Kubota M, Hirao K, Kawada R, Fujimoto S, Tanaka Y, Hazama M, Sugihara G, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Schizophr Bull Volume: 40(2) Pages: 420-7
  • Peer Reviewed
• [Journal Article] Superiority illusion arises from resting-state brain networks modulated by dopamine (2013)
  • Author(s): Yamada M, Uddin LQ, Takahashi H, Kimura Y, Takahata K, Kousa R, Ikoma Y, Eguchi Y, Takano H, Ito H, Higuchi M, Suhara T
  • Journal Title: Proc Natl Acad Sci U S A Volume: 110(11) Pages: 4363-7
  • Peer Reviewed
• [Journal Article] Molecular neuroimaging of emotional decision-making (2013)
  • Author(s): Takahashi H
  • Journal Title: Neurosci Res Volume: 75 Pages: 269-274
  • Peer Reviewed
• [Journal Article] Thalamocortical disconnection in the orbitofrontal region associated with cortical thinning in schizophrenia (2013)
  • Author(s): 13. Kubota M, Miyata J, Sasamoto A, Yoshida H, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: JAMA Psychiatry Volume: 70(1) Pages: 12-21
  • Peer Reviewed
• [Journal Article] Norepinephrine in the brain is associated with aversion to financial loss (2013)
  • Author(s): Takahashi H, Fujie S, Camerer C, Arakawa R, Takano H, Kodaka F, Matsui H, Ideno T, Okubo S, Takemura K, Yamada M, Eguchi Y, Murai T, Okubo Y, Kato M, Ito H, Suhara T
  • Journal Title: Mol Psychiatry Volume: 18 Pages: 3-4
  • Peer Reviewed
• [Journal Article] Monoamines and assessment of risks (2012)
  • Author(s): Takahashi H
  • Journal Title: Curr Opin Neurobiol Volume: 22(6) Pages: 1062-1067
  • Peer Reviewed
• [Journal Article] It's Not My Fault : Postdictive Modulation of Intentional Binding by Monetary Gains and Losses (2012)
  • Author(s): Takahata K, Takahashi H, Maeda T, Umeda S, Suhara T, Mimura M, Kato M
  • Journal Title: PLoS One Volume: 7(12) Pages: e53421
  • Peer Reviewed
• [Journal Article] Influence of contact with schizophrenia on implicit attitudes towards schizophrenia patients held by clinical residents (2012)
  • Author(s): Omori A, Tateno A, Ideno T, Takahashi H, Kawashima Y, Takemura K, Okubo Y
  • Journal Title: BMC Psychiatry Volume: 12 Pages: 205
  • Peer Reviewed
• [Journal Article] Alexithymia and reduced white matter integrity in schizophrenia : A diffusion tensor imaging study on impaired emotional self-awareness (2012)
  • Author(s): Kubota M, Miyata J, Sasamoto A, Kawada R, Fujimoto S, Tanaka Y, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Schizophr Res Volume: 141(2-3) Pages: 137-43
  • Peer Reviewed
• [Journal Article] Effect of Cooperation Level of Group on Punishment for a Non-cooperator : A Functional Magnetic Resonance Imaging Study (2012)
  • Author(s): Kodaka F, Takahashi H, Yamada M, Takano H, Nakayama N, Ito H, Suhara T
  • Journal Title: PLoS One Volume: 7 Pages: e41338
  • Peer Reviewed
• [Journal Article] Effects of sports participation on psychiatric symptoms and brain activations during sports observation in schizophrenia (2012)
  • Author(s): Takahashi H, Sassa S, Shibuya T, Kato M, Koeda M, Murai T, Matsuura M, Asai K, Suhara T, Okubo Y
  • Journal Title: Transl Psychiatry Pages: 2 e96
  • Peer Reviewed
• [Journal Article] Honesty mediates the relationship between serotonin and reaction to unfairness (2012)
  • Author(s): Takahashi H, Takano H, Camerer C, Ideno T, Okubo S, Matsui H, Tamari Y, Takemura K, Arakawa R, Yamada M, Eguchi Y, Murai T, Okubo Y, Kato M, Ito H, Suhara T
  • Journal Title: Proc Natl Acad Sci U S A Volume: 109(11) Pages: 4281-4284
  • Peer Reviewed
• [Journal Article] Emotional justice : Neural circuits mitigating criminal sentences (2012)
  • Author(s): Yamada M, Camerer CF, Kato M, Fujie S, Ito H, Suhara T, Takahashi H
  • Journal Title: Nature Commun Volume: 3 Pages: 759
  • Peer Reviewed
• [Journal Article] Functional significance of central D1dopamine receptors in cognition : beyond working memory (2012)
  • Author(s): Takahashi H, Yamada M, Suhara T
  • Journal Title: J Cereb Blood Flow Metab Volume: 32 Pages: 1248-1258
  • Peer Reviewed
• [Journal Article] Happiness is a matter of social comparison (2011)
  • Author(s): Yamada M, Takahashi H
  • Journal Title: Psychologia Volume: 54 Pages: 252-260
  • Peer Reviewed
• [Journal Article] Social impairment in schizophrenia revealed by Autistic Quotient correlated with gray matter reduction (2011)
  • Author(s): Sasamoto A, Miyata J, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Kubota M, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Soc Neurosci Volume: 6(5-6) Pages: 548-58
  • Peer Reviewed
• [Journal Article] Relation between Presynaptic and Postsynaptic Dopaminergic Functions Measured by Positron Emission Tomography : Implication of Dopaminergic Tone (2011)
  • Author(s): Ito H, Kodaka F, Takahashi H, Takano H, Arakawa R, Shimada H, Suhara T
  • Journal Title: J Neurosci Volume: 31(21) Pages: 7886-90
  • Peer Reviewed
• [Journal Article] Alexithymia and regional gray matter alterations in schizophrenia (2011)
  • Author(s): Kubota M, Miyata J, Hirao K, Fujiwara H, Kawada R, Fujimoto S, Tanaka Y, Sasamoto A, Sawamoto N, Fukuyama H, Takahashi H, Murai T
  • Journal Title: Neurosci Res Volume: 70 Pages: 206-213
  • Peer Reviewed
• [Journal Article] The neural mechanism of encountering misjudgment by the justice system
  • Author(s): Cui Q, Qinglin Q, Takahashi H
  • Journal Title: PLoS One Volume: 8(9) Pages: e75434
  • Peer Reviewed
• [Presentation] Understanding and defining phenotype of psychiatric disorders (2014)
  • Author(s): Takahashi H
  • Organizer: Japanese-French Frontiers of Science Symposium
  • Place of Presentation: Metz
  • Year and Date: 20140124-26
• [Presentation] ドーパミンの基礎的知見から統合失調症の症状を考えてみよう (2014)
  • Author(s): 高橋英彦
  • Organizer: 脳科学若手の会合宿
  • Place of Presentation: 相模原
  • Year and Date: 2014-03-29
• [Presentation] 精神・神経疾患の意思決定障害をターゲットにした薬物治療に向けて (2014)
  • Author(s): 高橋英彦
  • Organizer: 第87回日本薬理学会
  • Place of Presentation: 仙台市
  • Year and Date: 2014-03-21
• [Presentation] 情動的意思決定の脳イメージングヒューマンストレス (2014)
  • Author(s): 高橋英彦
  • Organizer: 産業技術研究会
  • Place of Presentation: 池田市
  • Year and Date: 2014-03-11
• [Presentation] Molecular neuroimaging of emotional decision-making (2013)
  • Author(s): Takahashi H
  • Organizer: International Symposium on Prediction and Decision Making
  • Place of Presentation: Kyoto
  • Year and Date: 20131013-14
• [Presentation] Molecular neuroimaging of emotional decision-making (2013)
  • Author(s): Takahashi H
  • Organizer: The Third International Symposium on "The Biology of Decision Making"
  • Place of Presentation: Paris
  • Year and Date: 20130529-30
• [Presentation] 先端研究を医療現場へ (2013)
  • Author(s): 高橋英彦
  • Organizer: 2013年第26回総合病院精神医学会
  • Place of Presentation: 京都
  • Year and Date: 2013-11-30
• [Presentation] Positive情動の認知神経科学 (2013)
  • Author(s): 高橋英彦
  • Organizer: 2013年第二回ポジティブサイコロジー医学会
  • Place of Presentation: 猪苗代
  • Year and Date: 2013-10-18
• [Presentation] Molecular neuroimaging of emotional decision-making (2013)
  • Author(s): Takahashi H
  • Organizer: Emotion Club Functional Imaging Laboratory University College London
  • Place of Presentation: London
  • Year and Date: 2013-05-28
• [Presentation] Effects of sport participation on social brain in schizophrenia (2013)
  • Author(s): Takahashi H
  • Organizer: 3rd Asian Conference on Schizophrenia Research
  • Place of Presentation: Bali
  • Year and Date: 2013-02-15
• [Presentation] 脳が行う意思決定の不思議～行動や脳機能画像を解析してわかること～ (2013)
  • Author(s): 高橋英彦
  • Organizer: 奈良女子大学附属中等教育学校Super science high schoolサイエンス先端講座
  • Place of Presentation: 奈良女子大学奈良
  • Year and Date: 2013-02-02
• [Presentation] Molecular neuroimaging of prefrontal functions (2012)
  • Author(s): Takahashi H
  • Organizer: International conference on prefrontal cortex
  • Place of Presentation: Kyoto
  • Year and Date: 20121129-30
• [Presentation] Molecular neuroimaging of emotional decision-making (2012)
  • Author(s): Takahashi H
  • Organizer: 2012 Korean Society for Brain and Neural Science
  • Place of Presentation: Seoul
  • Year and Date: 20120925-26
• [Presentation] Molecular neuroimaging of emotional decision-making (2012)
  • Author(s): Takahashi H
  • Organizer: 2012 International conference on Complex Medical Engineering
  • Place of Presentation: Kobe
  • Year and Date: 20120701-04
• [Presentation] Molecular neuroimaging of emotional decision-making (2012)
  • Author(s): Takahashi H
  • Organizer: 17th Annual International "Stress and Behavior" Neuroscience and Biopsychiatry Conference St. Petersburg
  • Place of Presentation: Russia
  • Year and Date: 20120516-19
• [Presentation] (2012)
  • Author(s): Takahashi H
  • Organizer: Japanese-French Frontiers of Science Symposium
  • Place of Presentation: Nice
  • Year and Date: 20120120-22
• [Presentation] 報酬系の異常として精神疾患は理解できるか? (2012)
  • Author(s): 高橋英彦
  • Organizer: 神経回路学会オータムスクール
  • Place of Presentation: 諏訪
  • Year and Date: 2012-11-25
• [Presentation] 依存症の脳生理と分子イメージング (2012)
  • Author(s): 高橋英彦
  • Organizer: 東京大学医科学研究所GCOE第五回疾患医科学ミニシンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2012-11-01
• [Presentation] うつ病のイメージングバイオマーカー(PET) (2012)
  • Author(s): 高橋英彦
  • Organizer: 生物学的精神医学会
  • Place of Presentation: 神戸
  • Year and Date: 2012-09-28
• [Presentation] Monoamine and decision making under risk (2012)
  • Author(s): 高橋英彦
  • Organizer: 日本神経科学会
  • Place of Presentation: 名古屋
  • Year and Date: 2012-09-21
• [Presentation] Molecular Imaging of emotional decision making (2012)
  • Author(s): 高橋英彦
  • Organizer: 日本心理学会
  • Place of Presentation: 川崎
  • Year and Date: 2012-09-11
• [Presentation] ニコチン依存の分子神経イメージング (2012)
  • Author(s): 高橋英彦
  • Organizer: 平成24年度アルコール・薬物依存関連学会合同学術総会
  • Place of Presentation: 札幌
  • Year and Date: 2012-09-07
• [Presentation] 社会的情動の認知神経科学 (2012)
  • Author(s): 高橋英彦
  • Organizer: 日本思春期青年期精神医学会
  • Place of Presentation: 広島
  • Year and Date: 2012-07-07
• [Presentation] 情動的意思決定の分子イメージング (2012)
  • Author(s): 高橋英彦
  • Organizer: 第7回日本分子イメージング学会
  • Place of Presentation: 浜松
  • Year and Date: 2012-05-25
• [Presentation] 情動的意思決定の脳科学 (2011)
  • Author(s): 高橋英彦
  • Organizer: 第3回医学教育シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2011-12-11
• [Presentation] Effect of sport participation on brain activations. Social cognition in schizophrenia : from the neurobiological basis to clinical remediation (2011)
  • Author(s): Takahashi H
  • Organizer: 15th World Congress of Psychiatry
  • Place of Presentation: Buenos Aires
  • Year and Date: 2011-09-20
• [Presentation] 情動的意思決定の分子イメージング (2011)
  • Author(s): 高橋英彦
  • Organizer: 第34回日本神経科学大会シンポジウム
  • Place of Presentation: 横浜
  • Year and Date: 2011-09-16
• [Presentation] Molecular Imaging of emotional decision making (2011)
  • Author(s): 高橋英彦
  • Organizer: 大阪バイオサイエンス研究所セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2011-04-20
• [Book] 分子神経イメージングによる神経経済学の発展プレインサイエンス・レビュー2014廣川信隆編 (2014)
  • Author(s): 高橋英彦
  • Total Pages: 113-128
• [Book] なぜ他人の不幸は蜜の味なのか (2014)
  • Author(s): 高橋英彦
  • Total Pages: 176
  • Publisher: 幻冬舎ルネッサンス