2013 Fiscal Year Final Research Report
High-dense CMOS electrode array to investigate neuronal network in culture
| Project/Area Number |
23680050
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 神経細胞 / 脳 / ネットワーク / 培養 / 電極 / CMOS / 可塑性 / 神経回路 |
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| Research Abstract |
The network configuration and activities in dissociated cultures of neurons were investigated using high-density CMOS microelectrode array with 11,011 recording sites within 1.8 x 1.8 mm2. Our data demonstrated that the conduction velocity of action potential along an axon varies within an identical cell; the velocity was high at thick parts of axon, while low at thin parts. We also demonstrated that low-firing-rate neurons migrate actively. Furthermore, spatio-temporal patterns evoked by single axon stimulation were proved useful to quantify the functional connectivity and plasticity within the network.
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