2013 Fiscal Year Final Research Report
Design of minimum ECM using cell-selective peptides for medical implant coating
| Project/Area Number |
23680055
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Nagoya University |
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Principal Investigator |
KATO Ryuji 名古屋大学, 創薬科学研究科, 准教授 (50377884)
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| Co-Investigator(Renkei-kenkyūsha) |
NARITA Yuji 名古屋大学, 医学系研究科, 講師 (60378221)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 細胞選択性 / ECM / 人工血管 / ポリカプロラクトン / エレクトロスピニング / クリックケミストリー / ペプチドマイクロアレイ / 再生促進 |
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| Research Abstract |
This research was conducted to develop novel bio-material for the coating organic molecules for next generation medical implants. Especially, we focused to find the Minimum short peptide sequences to construct artificial Extracellular Matrix (ECM) to function as cell-selective performance. We succeeded to exhaustively screen the 8000 short peptide libraries for their cellular selectivity, anti-thrombosis effect, and ECM adhesive effect and found the minimum sequences and their rankings to construct artificial ECM.
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[Journal Article] Collagen type IV-specific tripeptides for selective adhesion of endothelial and smooth muscle cells2012
Author(s)
Kanie K, Narita Y, Zhao Y, Kuwabara F, Satake M, Honda S, Kaneko H, Yoshioka T, Okochi M, Honda H, Kato R
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Journal Title
Biotechnology Bioengineering
Volume: 109(7)
Pages: 1808-1816
Peer Reviewed
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