2012 Fiscal Year Final Research Report
Roles of Notch signaling pathway in colon cancer metastasis
| Project/Area Number |
23680088
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Tumor biology
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転移 / 遺伝子改変動物 |
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| Research Abstract |
Cancer is the leading cause of death in most industrialized nations, and the direct cause of cancer death is often its metastasis to the vital organs. In this study, we demonstrate that Notch signaling regulates activities of Rho family small GTPases to stimulate invasion and metastasis of colon cancer. On the other hand, activation of PIK3CAin Apc mutant mice caused massive local invasion of intestinal tumors. These results raise novel therapeutic targets in invasion and metastasis of colon cancer.
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[Journal Article] Molecular mechanisms of liver metastasis.2011
Author(s)
Kawada K, Hasegawa S, Murakami T, Itatani Y, Hosogi H, Sonoshita M, Kitamura T, Fujishita T, Iwamoto M, Matsumoto T, Matsusue R, Hida K, Akiyama G, Okoshi K, Yamada M, Kawamura J, Taketo MM, Sakai Y
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Journal Title
Int. J. Clin. Oncol
Volume: 16
Pages: 464-472
DOI
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