2013 Fiscal Year Final Research Report
Development of biofabrication techniques for living cells towards cell and tissue engineering
| Project/Area Number |
23681027
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Microdevices/Nanodevices
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| Research Institution | Tohoku University |
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Principal Investigator |
KAJI Hirokazu 東北大学, 工学(系)研究科(研究院), 准教授 (70431525)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | バイオファブリケーション / 生体材料 / マイクロ・ナノデバイス / 細胞・組織 |
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| Research Abstract |
Developing fabrication process under physiological conditions is of significance in order to utilize the maximum function of biosources such as proteins and living cells. In this project, biofabrication techniques to endure the fragility of living cells were developed towards in vitro cell and tissue engineering. The combination of microfluidic technique, soft lithographic technique, and surface engineering with hydrogels and polymeric nanosheets enabled the development of 2D and 3D cell culture systems capable of controlling cellular environments and it is demonstrated that these systems are useful for the formation of functional tissues including muscles.
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[Journal Article] A Polymeric Platform for Controlled Dual-Drug Delivery to the Retina: Protective Effects against Light-Induced Retinal Damage in Rats2014
Author(s)
Nobuhiro Nagai, Hirokazu Kaji, Hideyuki Onami, Yuki Katsukura, Yumi Ishikawa, Zhaleh Kashkouli Nezhad, Kaori Sampei, Satoru Iwata, Shuntaro Ito, Matsuhiko Nishizawa, Toru Nakazawa, Noriko Osumi, Yukihiko Mashima, Toshiaki Abe
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Journal Title
Adv. Healthcare Mater
Volume: (in press)
DOI
Peer Reviewed
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[Journal Article] Electrically regulated differentiation of skeletal muscle cells on ultrathin graphene-based films2014
Author(s)
Samad Ahadian, Javier Ramón-Azcón, Haixin Chang, Xiaobin Liang, Hirokazu Kaji, Hitoshi Shiku, Ken Nakajima, Murugan Ramalingam, Hongkai Wu, Tomokazu Matsue, Ali Khademhosseini
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Journal Title
RSC Advances
Volume: 4
Pages: 9534-9541
DOI
Peer Reviewed
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[Journal Article] Dielectrophoretically aligned carbon nanotubes to control electrical and mechanical properties of hydrogels to fabricate contractile muscle myofibers2013
Author(s)
Javier Ramón-Azcón, Samad Ahadian, Mehdi Estili, Xiaobin Liang, Serge Ostrovidov, Hirokazu Kaji, Hitoshi Shiku, Murugan Ramalingam, Ken Nakajima, Yoshio Sakka, Ali Khademhosseini, Tomokazu Matsue
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Journal Title
Adv. Mater.
Volume: 25
Pages: 4028-4034
DOI
Peer Reviewed
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[Journal Article] Gelatin methacrylate as a promising hydrogel for 3D microscale organization and proliferation of dielectrophoretically patterned cells2012
Author(s)
Javier Ramón-Azcón, Samad Ahadian, Raquel Obregón, Gulden Camci-Unal, Serge Ostrovidov, Vahid Hosseini, Hirokazu Kaji, Kosuke Ino, Hitoshi Shiku, Ali Khademhosseini, Tomokazu Matsue
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Journal Title
Lab Chip
Volume: 12
Pages: 2959-2969
DOI
Peer Reviewed
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[Book] "Bioinspired Muscle Tissue Devices" In Handbook of Biomimetics and Bioinspiration: 3 Volume Set, E. Jabbari, A. Khademhosseini, L. P. Lee, D.-H. Kim, A. Ghaemmaghami Eds.2014
Author(s)
Toshinori Fujie, Serge Ostrovidov, Samad Ahadian, S. Prakash Parthiban, Ali Khademhosseini, Hirokazu Kaji
Publisher
World Scientific Publishing
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[Book] MRS Symposium Proceesings Volume 1415, MEMS, BioMEMS and Bioelectronics – Materials and Devices, (pp. 1-221)2012
Author(s)
Tim Albrecht, Maarten P. de Boer, Frank W. DelRio, Mehmet R. Dokmeci, Cristoph Eberl, Junji Fukuda, Hirokazu Kaji, Chris Keimel, Ali Khademhosseini
Publisher
Cambridge University Press
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