2013 Fiscal Year Final Research Report
Controlling cell function by synthetic biology approaches
| Project/Area Number |
23681042
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
System genome science
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| Research Institution | Kyoto University |
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Principal Investigator |
SAITO Hirohide 京都大学, 白眉センター, 准教授 (20423014)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 合成生物学 / RNA / 翻訳 / RNP / バイオエンジニアリング |
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| Research Abstract |
It is important to develop a method that controls gene expression dependent on intracellular environment.In synthetic biology field, researchers aim to understand life and develop new biotechnologies through the process of designing and constructing biomolecules and biological systems. However, designing functional biomolecules and systems to control cell function has remained a challenge. In this study, we designed synthetic "RNA switches" that detect specific proteins expressed in cells and control expression of target genes. As a result, we generated several RNA switches that function in mammalian cells (Nucleic Acids Res. 40:9369, 2012, Nucleic Acids Res. 41:e135, 2013, Nature Commun. 4:2393,2013).
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