Activation of chemical bonds between main-elements in body by multifunctional copper catalysts

2014 Fiscal Year Final Research Report

• Project/Area Number: 23685008
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Organic chemistry
• Research Institution: Tohoku University
• Principal Investigator: NAKAMURA Itaru 東北大学, 理学(系)研究科(研究院), 准教授 (00333899)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 結合活性化 / 銅触媒 / ヘテロ環 / 転位反応 / ドミノ反応 / 効率的合成 / 環境調和型分子変換

Outline of Final Research Achievements

In this investigation, we developed several synthetic reactions involving cleavage of sigma bonds between "main elements in body" by the use of multi-functional copper catalysts. In particular, we developed skeletal rearrangement and cascade reactions employing O-propargylic oximes as the substrate. These reaction involves cleavage of C-O and/or N-O bonds. Copper catalysts consecutively functioned not only pi-activation catalyst but also sigma acids and single-electron transfer catalysts. Moveover, our investigations realized efficient synthesis of new class of heterocyclic compounds, such as four-membered cyclic nitrones, pyridine-N-oxides, dihydropyrimidines, triazines, and oxazepines.

Free Research Field

反応有機化学