Preparation of Sulfonated Glycopolymer Libraries and Development of Pathogen Removal Materials

2014 Fiscal Year Final Research Report

• Project/Area Number: 23685027
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Polymer chemistry
• Research Institution: Kyushu University
• Principal Investigator: MIURA Yoshiko 九州大学, 工学(系)研究科(研究院), 教授 (00335069)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 糖鎖高分子 / 高分子合成 / グリコサミノグリカン / 硫酸化糖 / 表面修飾 / 分離

Outline of Final Research Achievements

The glycopolymers having sulfonated N-acetyl glucosamine (GlcNAc) were synthesized, and the biological activities of the polymers were investigated. Glycosaminoglycans are the bioactive polysaccharides, which involves in the various living systems. Since the syntheses of glycosaminoglycans are difficult, the applicant investigated the new method to mimic the function of glycosaminoglycans by biopolymers. Site selective sulfonation of GlcNAc was performed and the acrylamide phenyl derivatives of sulfonated GlcNAc were synthesized. The polymers were synthesized with radical initiator. The biological activities with proteins were investigated. The polymers showed the affinities to the proteins of Alzheimer disease and cell growth factors. The porous materials with glycopolymers was also investigated. The siliceous porous materials were modified by poymer grafting and the protein separation was investigated.

Free Research Field

生体関連高分子