2013 Fiscal Year Final Research Report
Fundamental study on physiological properties of polymer-brush-afforded hybrid particles
| Project/Area Number |
23685049
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Polymer/Textile materials
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| Research Institution | Kyoto University |
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Principal Investigator |
OHNO Kohji 京都大学, 化学研究所, 准教授 (00335217)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | リビングラジカル重合 / グラフト重合 / ポリマーブラシ / 微粒子 / 体内動態 |
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| Research Abstract |
Perfectly dispersive polymer-brush-afforded hybrid particles were synthesized by surface-initiated living radical polymerization. The protein adsorption properties and circulation lifetime in the blood of the resultant hybrids particles were significantly dependent on their structural parameters. Some hybrid particles exhibiting an excellently prolonged circulation lifetime preferentially accumulated in tumor tissue. The tumor-targeted delivery was optically visualized using hybrid particles grafted with fluorescence-labeled polymer brushes. In addition, the tumor-targeted delivery of polymer-brush-afforded iron oxide nanoparticles was visualized by an MRI measurement.
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