2012 Fiscal Year Final Research Report
Relation analysis between odorant receptors and specific behaviors in mammls
| Project/Area Number |
23687003
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | 公益財団法人大阪バイオサイエンス研究所 (2012)
Osaka Bioscience Institute (2011) |
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Principal Investigator |
KOBAYAKAWA Ko 公益財団法人大阪バイオサイエンス研究所, 神経機能学部門, 研究員 (60466802)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 嗅覚 / 情動 |
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| Research Abstract |
We identified a series of odorants (fear odors) which has extremely strong activity to induce innate freezing behaviors in mice. We clarified rules of chemical structures ,which is indispensable to induce innate fear emotions. We cloned about 1000 odorant receptors, representing almost all of mouse odorant receptors in the mouse genome, to develop an expression screening system , and analyzed the binding specificity of fear odors and odorant receptors. As a result, we clarified the possibility that, in addition to the specificities of odorant receptors, chemical structures of odorants are also important to induce fear emotions. We identified a number of animal species that specifically respond to fear odors.
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[Journal Article] Parallel mitral and tufted cell pathways route distinct odor information to different targets in the olfactory cortex2012
Author(s)
Igarashi K M*, Iseki N, An M, Yamaguchi Y, Nagayama S, Kobayakawa K, Kobayakawa R, Tanifuji M, Sakano H, Chen W R, and Mori K
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Journal Title
Neuroscience
Volume: 32(23)
Pages: 7970-7985
DOI
Peer Reviewed
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