2013 Fiscal Year Final Research Report
Genetic adaptation to agriculture in Asians: Insights from lifestyle-related diseases
| Project/Area Number |
23687036
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Physical anthropology
|
|---|
| Research Institution | Jichi Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | ゲノム多様性 / 生活習慣病 / SNP / モンゴル人 / 適応 |
|---|
| Research Abstract |
Mongolians, a nomadic group in East Asia, are different from agricultural East Asians in susceptibility to lifestyle-related diseases. Genetic adaptation to the distinctive occupations would partly contribute to the ethnic differences in the disease susceptibility. The present anthropological, genetic-epidemiological study revealed that Mongolians and agricultural East Asians (Japanese and Han Chinese) showed large genetic differentiations in gene sets related to metabolic disorders, including alcohol metabolism, fatty acid metabolism, gluconeogenesis/glycolysis, and adipogenesis. Additionally, novel gene influencing visceral fat accumulation in East Asians (TRIB2) was identified.
|
