Roles of cohesin and condensin in mammalian meiosis

2014 Fiscal Year Final Research Report

• Project/Area Number: 23688036
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Applied animal science
• Research Institution: Kobe University
• Principal Investigator: LEE Jibak 神戸大学, (連合)農学研究科(研究院), 准教授 (50372660)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 減数分裂 / 染色体 / コヒーシン / コンデンシン / 卵母細胞 / 精母細胞

Outline of Final Research Achievements

The purpose of the present study is to reveal the molecular mechanism underlying chromosome behavior during meiosis in mammals. We revealed for the first time that condensins I and II are involved in chromosome condensation and segregation during meiosis and early embryonic development in mice. We also showed the detailed localization of meiotic cohesin subunits, RAD21L and REC8, both of which are known to be essential for synapsis and recombination of homologous chromosomes in mammalian meiosis.

Free Research Field

発生工学