2013 Fiscal Year Final Research Report
Development of tumor associated macrophages-selective DDS and its application to tumor therapy
| Project/Area Number |
23689003
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Nagasaki University (2013)
Kyoto University (2011-2012) |
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Principal Investigator |
KAWAKAMI Shigeru 長崎大学, 医歯(薬)学総合研究科, 教授 (20322307)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | ＤＤＳ / ターゲティング / リポソーム / 超音波 / 腫瘍関連マクロファージ / マンノース修飾リポソーム |
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| Research Abstract |
Tumor-associated macrophages (TAM) exhibit an M2 phenotype that promotes tumor progression, and conversion of M2 TAM toward a tumouricidal M1 phenotype is a promising anti-cancer therapy. However, little has been reported on TAM-selective drug delivery because a specific ligand is lacked. Mannosylated carriers would be an effective approach, but they can be distributed to all of macrophages that highly expressed mannose receptors in the body. In this study, we succeeded to develop a mannosylated bubble lipoplex and ultrasound irradiation to tumor site for TAM-selective delivery of nucleic acid.
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[Journal Article] Kidney-selective gene transfection using anionic bubble lipopolyplexes with renal ultrasound irradiation in mice2014
Author(s)
T. Kurosaki, S. Kawakami, Y. Higuchi, R. Suzuki, K. Maruyama, H. Sasaki, F. Yamashita, M. Hashida
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Journal Title
Nanomedicine, Nanotechnology, Biology, and Medicine
Volume: (in press)
Peer Reviewed
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