Investigation on the molecular basis of neuropeptide receptors for the regulation of reproductive systems

2014 Fiscal Year Final Research Report

• Project/Area Number: 23689007
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Drug development chemistry
• Research Institution: Kyoto University
• Principal Investigator: OISHI Shinya 京都大学, 薬学研究科(研究院), 講師 (80381739)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 性ホルモン / キスペプチン / GPR54 / ニューロキニン / 受容体 / プローブ

Outline of Final Research Achievements

Novel selective ligands and specific molecular probes for kisspeptin receptor (GPR54) and neurokinin receptor were developed. Fluorescent probes and photoaffinity probes for kisspeptin receptor were designed and synthesized. These probes were applicable to the detection of GPR54 in confocal microscopy analysis, flow cytometry and photolabeling experiments. Additionally, novel NK3 receptor agonists with resistance against peptidase-mediated degradation were developed via the structure-activity relationship studies using a number of peptidomimetics.

Free Research Field

創薬化学