2013 Fiscal Year Final Research Report
Controlling cellular function via modulating cytosolic chloride dynamics
| Project/Area Number |
23689011
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | University of Fukui (2013)
Kyoto University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Keywords | Ｃｌダイナミクス / Ｃａダイナミクス / 細胞内小器官 |
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| Research Abstract |
The purpose of the present study was to clarify the mechanisms and significances of "cellular Cl-Ca dynamics coupling". To achieve the goals, I picked up two kinds of cells, cardiomyocytes and lymphocytes as typical excitable and non-excitable cells, respectively, and performed a combination study of cellular physiological experiments and mathematical simulations. As a result, I obtained following achievements. 1. There is an intracellular Cl store which is involved in the cellular Cl dynamics. 2. "Cellular Cl-Ca dynamics coupling" do exist. 3. Mitochondria are major organelle which participate in the "cellular Cl-Ca dynamics coupling".
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[Journal Article] Impairment of Ubiquitin-Proteasome System by E334K cMyBPC Modifies Channel Proteins, Leading to Electrophysiological Dysfunction2011
Author(s)
Bahrudin U, Morikawa K, Takeuchi A, Kurata Y, Miake J, Mizuta E, Adachi K, Higaki K, Yamamoto Y, Shirayoshi Y, Yoshida A, Kato M, Yamamoto K, Nanba E, Morisaki H, Morisaki T, Matsuoka S, Ninomiya H, Hisatome I
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Journal Title
Journal of Molecular Biology
Volume: 413(4)
Pages: 857-878
DOI
Peer Reviewed
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