2013 Fiscal Year Final Research Report
Analysis of a novel D-Serine signaling underlying synaptic plasticity and motor learning
| Project/Area Number |
23689012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General physiology
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 神経科学 / 生理学 / 生体分子 / アミノ酸 / シナプス |
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| Research Abstract |
In this study, we examined the functional role of a D-serine highly existing in the developing cerebella. D-Serine in the cerebellum, which was released from glial cells in a neuronal activity-dependent manner, bound to the postsynaptically-expressing delta2-type ionotropic glutamate receptors (delta2 receptors) to regulate synaptic plasticity, a molecular basis of learning and memory. Interestingly, we revealed that delta2 receptor controlled the synaptic plasticity by binding to the tyrosine phosphatase PTPMEG via its intracellular C-terminus. Thus, D-serine-delta2 signaling is a unique D-serine signaling, which may gain new insights into the glia-neuron interaction.
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[Journal Article] CAPS1 deficiency perturbs dense-core vesicle trafficking and Golgi structure and reduces presynaptic release probability in the mouse brain2013
Author(s)
Sadakata T, Kakegawa W, Shinoda Y, Hosono M, Katoh-Semba R, Sekine Y, Sato Y, Tanaka M, Iwasato T, Itohara S, Furuyama K, Kawaguchi Y, Ishizaki Y, Yuzaki M, Furuichi T
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Journal Title
J Neurosci
Volume: 33
Pages: 17326-17334
DOI
Peer Reviewed
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[Journal Article] Deletions in GRID2 lead to a recessive syndrome of cerebellar ataxia and tonic upgaze in humans2013
Author(s)
Hills LB, Masri A, Konno K, Kakegawa W, Lam AT, Lim-Melia E, Chandy N, Hill RS, Partlow JN, Al-Saffar M, Nasir R, Stoler JM, Barkovich AJ, Watanabe M, Yuzaki M, Mochida GH
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Journal Title
Neurology
Volume: 81
Pages: 1378-1386
DOI
Peer Reviewed
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[Journal Article] NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂is essential for AMPA receptor endocytosis during LTD2012
Author(s)
Unoki T, Matsuda S, Kakegawa W, Van NT, Kohda K, Suzuki A, Funakoshi Y, Hasegawa H, Yuzaki M, Kanaho Y
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Journal Title
Neuron
Volume: 73
Pages: 135-148
DOI
Peer Reviewed
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[Journal Article] D-serine regulates cerebellar LTD and motor coordination through theδ2 glutamate receptor2011
Author(s)
Kakegawa W, Miyoshi Y, Hamase K, Matsuda S, Matsuda K, Kohda K, Emi K, Motohashi J, Konno R, Zaitsu K, Yuzaki M
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Journal Title
Nat Neurosci
Volume: 14
Pages: 603-611
DOI
Peer Reviewed
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