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2013 Fiscal Year Final Research Report

The role of tandem repeat antigens in immune escape

Research Project

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Project/Area Number 23689024
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Parasitology (including Sanitary zoology)
Research InstitutionThe University of Tokyo

Principal Investigator

YASUYUKI Goto  東京大学, 農学生命科学研究科, 准教授 (50553434)

Project Period (FY) 2011-11-18 – 2014-03-31
Keywords抗原 / タンデムリピート / 寄生虫 / リーシュマニア症
Research Abstract

Tandem repeat (TR) proteins of protozoan parasites have been reported as strong B cell antigens, whereas the mechanisms for the antigenicity or the biological meaning of the antigenic TR proteins remain unknown. In this study, we revealed through genome analyses of Kinetoplastida parasites that the presence of huge TR genes is related to the pathogenesis to mammals. Besides, we found a distinct antibody production pattern to TR antigens compared to non-TR antigens, indicating the unique mechanism for TR antigens to be recognized by B cells. Furthermore, we identified BAFF as a candidate molecule related to excessive activation of humoral responses during leishmaniasis. Taken together, these findings will be a great step towards understanding immune escape mechanisms of protozoan parasites by using TR antigens.

  • Research Products

    (32 results)

All 2014 2013 2012

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (28 results) Book (1 results)

  • [Journal Article] 犬のリーシュマニア症2013

    • Author(s)
      松本芳嗣、後藤康之、三條場千寿
    • Journal Title

      日本獣医師会雑誌

      Volume: 66 Pages: 5-7

  • [Journal Article] Utilization of ELISA Using Thioredoxin Peroxidase-1 and Tandem Repeat Proteins for Diagnosis of Schistosoma japonicum Infection among Water Buffaloes2012

    • Author(s)
      Angeles JM, Goto Y, Kirinoki M, Asada M,Leonardo LR, Rivera PT, Villacorte EA, Inoue N, Chigusa Y, Kawazu S
    • Journal Title

      PLoS Negl Trop Dis

      Volume: 6 Pages: e1800

    • DOI

      10.1371/journal.pntd.0001800.

    • Peer Reviewed
  • [Journal Article] リーシュマニア症に対するワクチン開発の展望2012

    • Author(s)
      後藤康之
    • Journal Title

      獣医寄生虫学会誌

      Volume: 11 Pages: 1-7

    • Peer Reviewed
  • [Presentation] 実験的内臓型リーシュマニア症における治療後の再感染抵抗性2014

    • Author(s)
      長田康孝、関信弥、松井洋輔、三條場千寿、後藤康之、松本芳嗣
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛大学、松山
    • Year and Date
      2014-03-28
  • [Presentation] 実験的内臓型リーシュマニア症における血中IgGの異常亢進2014

    • Author(s)
      大間知聡子、三條場千寿、後藤康之、松本芳嗣
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛大学、松山
    • Year and Date
      2014-03-28
  • [Presentation] Anti-Leishmania IgE antibodies : a bio-maker for characterization of cutaneous leishmaniasis2014

    • Author(s)
      孫家梅、イゴーリハタンバター、Yusuf Ozbel、長田康孝、三條場千寿、後藤康之、松本芳嗣
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛大学、松山
    • Year and Date
      2014-03-28
  • [Presentation] Detection of canine schistosomiasis japonica using recombinant thioredoxin peroxidase-1 and tandem repeat proteins2014

    • Author(s)
      Angeles J、後藤康之、桐木雅史、Leonardo L、Nicasio B、Hakimi H、Lee S、Rivera P、Villacorte E、井上昇、千種雄一、河津信一郎
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛大学、松山
    • Year and Date
      2014-03-28
  • [Presentation] Search for Anti-leishmanial Compounds from Marine Sponge2013

    • Author(s)
      Wen D, Ishigami D, Goto Y, Matsumoto Y, Kanto K, Nakao Y
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド、神戸
    • Year and Date
      2013-12-04
  • [Presentation] Involvement of IgE responses in experimental cutaneous leishmaniasis2013

    • Author(s)
      Sun J, Igori K, Omachi S, Osada Y, Sanjoba C, Goto Y, Matsumoto Y
    • Organizer
      第73回日本寄生虫学会東日本支部大会
    • Place of Presentation
      国立科学博物館、東京
    • Year and Date
      2013-10-12
  • [Presentation] Detection of canine schistosomiasis japonica using recombinant thioredoxin peroxidase-1 and tandem repeat proteins2013

    • Author(s)
      AngelesJ、後藤康之、Leonardo L、桐木雅史、Hakimi H、Tongol-Rivera P、Villacorte W、井上昇、千種雄一、河津信一郎
    • Organizer
      第54回日本熱帯医学会大会
    • Place of Presentation
      長崎ブリックホール、長崎
    • Year and Date
      2013-10-05
  • [Presentation] Application of tandem repeat recombinant proteins as potential antigens for the sero-diagnostic test of Schistosoma mansoni infection2013

    • Author(s)
      Dan Y、Kato K、Goto Y、Fujii Y、Hamano S
    • Organizer
      第54回日本熱帯医学会大会
    • Place of Presentation
      長崎ブリックホール、長崎
    • Year and Date
      2013-10-05
  • [Presentation] Susceptibility and resistance correlates with differential expansion of helper T cell subsets in experimental murine visceral leishmaniasis2013

    • Author(s)
      Osada Y, Seki M, Sanjoba C, Goto Y, Matsumoto Y
    • Organizer
      Worldleish5
    • Place of Presentation
      Enotel, Porto de Galinhas, Brazil
    • Year and Date
      2013-05-17
  • [Presentation] Tandem repeat proteins for serological diagnosis of visceral leishmaniasis2013

    • Author(s)
      Goto Y, Sanjoba C, Reed SG, Noiri E, Matsumoto Y
    • Organizer
      Worldleish5
    • Place of Presentation
      Enotel, Porto de Galinhas, Brazil
    • Year and Date
      2013-05-14
  • [Presentation] Kala Azar in South Asia–current status and challenges ahead : vector surveillance studies in Bangladesh; hints and hopes2013

    • Author(s)
      Ozbel Y, Sanjoba C, Goto Y, Noiri E, Matsumoto Y
    • Organizer
      Worldleish5
    • Place of Presentation
      Enotel, Porto de Galinhas, Brazil.
    • Year and Date
      2013-05-14
  • [Presentation] In silico identification of vaccine antigens for leishmaniasis2013

    • Author(s)
      Goto Y, Yamagishi J, Sanjoba C, Reed SG, Matsumoto Y
    • Organizer
      Worldleish5
    • Place of Presentation
      Enotel, Porto de Galinhas, Brazil.
    • Year and Date
      2013-05-14
  • [Presentation] 海藻類Sargassum yamadaeより単離したキノンテルペノイドの抗リーシュマニア症活性2013

    • Author(s)
      長田康孝、三條場千寿、木村純二、後藤康之、松本芳嗣
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2013-03-31
  • [Presentation] Localization and expression profiling of a 31 kDa antigenic repetitive protein Sjp_0110390 in Schistosoma japonicum life stages2013

    • Author(s)
      Angeles J, Kirinoki M, Goto Y, Asada M, Hakimi H, Leonardo L, Rivera P, Villacorte E, Inoue N, Chigusa Y, Kawazu S
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2013-03-30
  • [Presentation] Reverse vaccinologyによるリーシュマニア症ワクチン抗原の探索2013

    • Author(s)
      後藤康之、山岸潤也、長田康孝、三條場千寿、松本芳嗣
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京医科歯科大学、東京
    • Year and Date
      2013-03-29
  • [Presentation] Villacorte E, Inoue N, Chigusa Y, Kawazu S. Development of recombinant antigen-based serological diagnosis for the detection of Schistosoma japonicum infection in water buffaloes2013

    • Author(s)
      Angeles J, Goto Y, Kirinoki M, Asada M, Leonardo L, Tongol Rivera P
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2013-03-28
  • [Presentation] マウス実験的内臓型リーシュマニア症におけるTh1、Th2の感受性、抵抗性への関与2013

    • Author(s)
      長田康孝、関信弥、三條場千寿、後藤康之、松本芳嗣
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京大学、東京
    • Year and Date
      2013-03-28
  • [Presentation] Development of Immunochromatographic Test (ICT) for Animal Trypanosomosis2012

    • Author(s)
      Nguyen T, Goto Y, Lun Z, Kawazu S, Inoue N
    • Organizer
      第53回日本熱帯医学会大会
    • Place of Presentation
      とかちプラザ、帯広
    • Year and Date
      20120905-06
  • [Presentation] リーシュマニア症ワクチン抗原の有用性に寄与するパラメータの探索2012

    • Author(s)
      後藤康之、山岸潤也、長田康孝、三條場千寿、松本芳嗣
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学、岩手
    • Year and Date
      2012-09-16
  • [Presentation] Tongol-Rivera P, Villacorte E, Inoue N, Chigusa Y, Kawazu S. Evaluation of Recombinant Proteins for Schistosoma japonicum Infection Diagnosis among Water Buffaloes in Two New Endemic Foci in the Philippines2012

    • Author(s)
      Angeles J, Goto Y, Kirinoki M, Asada M, Leonardo L
    • Organizer
      第53回日本熱帯医学会大会
    • Place of Presentation
      とかちプラザ、帯広
    • Year and Date
      2012-09-06
  • [Presentation] Antigen Discovery for Serological Diagnosis of Visceral Leishmaniasis. Third International Conference on Neglected Tropical Diseases2012

    • Author(s)
      Goto Y
    • Organizer
      Bangladesh and Scientific Meeting on Kala-azar and PKDL
    • Place of Presentation
      Filaria and General Hospital, Savar, Bangladesh.
    • Year and Date
      2012-09-02
  • [Presentation] 実験的内臓型リーシュマニア症におけるMRP8、14陽性細胞の増加2012

    • Author(s)
      長田康孝、大間知聡子、三條場千寿、後藤康之、松本芳嗣
    • Organizer
      第20回分子寄生虫学ワークショップ
    • Place of Presentation
      神戸セミナーハウス、神戸
    • Year and Date
      2012-08-26
  • [Presentation] リーシュマニア原虫の抗原学2012

    • Author(s)
      後藤康之、三條場千寿、Steve Reed、松本芳嗣
    • Organizer
      第20回分子寄生虫学ワークショップ
    • Place of Presentation
      神戸セミナーハウス、神戸
    • Year and Date
      2012-08-26
  • [Presentation] 実験的Leishmania donovani感染マウス血液からの原虫分離2012

    • Author(s)
      長田康孝、三條場千寿、麻田正仁、後藤康之、松本芳嗣
    • Organizer
      第153回日本獣医学会学術集会
    • Place of Presentation
      大宮ソニックシティ、大宮
    • Year and Date
      2012-03-28
  • [Presentation] Leonardo L, Tongol-Rivera P, Villacorte E, Inoue N, Chigusa Y, Kawazu S. Serological Comparison of Recombinant Thioredoxin Peroxidase-1 and Tandem Repeat Proteins for Detection of Human and Animal Schistosoma japonicum Infection2012

    • Author(s)
      Angeles J, Goto Y, Kirinoki M, Asada M
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      兵庫医科大学、西宮
    • Year and Date
      2012-03-24
  • [Presentation] バベシア原虫細胞内酸化ストレスの可視化2012

    • Author(s)
      麻田正仁、薄井美帆、後藤康之、横山直明、井上昇、河津信一郎
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      兵庫医科大学、西宮
    • Year and Date
      2012-03-24
  • [Presentation] 内臓型リーシュマニア症in vivoモデルを用いたAmBisomeの抗リーシュマニア症活性2012

    • Author(s)
      長田康孝、三條場千寿、麻田正仁、後藤康之、松本芳嗣
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      兵庫医科大学、西宮
    • Year and Date
      2012-03-23
  • [Presentation] Commonness and uniqueness of tandem repeat antigens in the trypanosomatid parasites2012

    • Author(s)
      後藤康之、Carter D、Duthie M、河津信一郎、井上昇、Reed S、松本芳嗣
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      兵庫医科大学、西宮
    • Year and Date
      2012-03-23
  • [Book] Section 5, 25.2 Current approaches to the development of a vaccine against leishmaniasis. "Immunity to Parasitic Infections"2012

    • Author(s)
      Goto Y, Reed SG(edited by Tracey Lamb)
    • Total Pages
      431-440
    • Publisher
      Wiley–Blackwell

URL: 

Published: 2015-07-16  

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