2013 Fiscal Year Final Research Report
The role of tandem repeat antigens in immune escape
| Project/Area Number |
23689024
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Parasitology (including Sanitary zoology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YASUYUKI Goto 東京大学, 農学生命科学研究科, 准教授 (50553434)
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Keywords | 抗原 / タンデムリピート / 寄生虫 / リーシュマニア症 |
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| Research Abstract |
Tandem repeat (TR) proteins of protozoan parasites have been reported as strong B cell antigens, whereas the mechanisms for the antigenicity or the biological meaning of the antigenic TR proteins remain unknown. In this study, we revealed through genome analyses of Kinetoplastida parasites that the presence of huge TR genes is related to the pathogenesis to mammals. Besides, we found a distinct antibody production pattern to TR antigens compared to non-TR antigens, indicating the unique mechanism for TR antigens to be recognized by B cells. Furthermore, we identified BAFF as a candidate molecule related to excessive activation of humoral responses during leishmaniasis. Taken together, these findings will be a great step towards understanding immune escape mechanisms of protozoan parasites by using TR antigens.
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[Presentation] Localization and expression profiling of a 31 kDa antigenic repetitive protein Sjp_0110390 in Schistosoma japonicum life stages2013
Author(s)
Angeles J, Kirinoki M, Goto Y, Asada M, Hakimi H, Leonardo L, Rivera P, Villacorte E, Inoue N, Chigusa Y, Kawazu S
Organizer
第82回日本寄生虫学会大会
Place of Presentation
東京医科歯科大学、東京
Year and Date
2013-03-30
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