2013 Fiscal Year Final Research Report
Development of new therapeutic tools against pathogenic bacteria
| Project/Area Number |
23689027
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KIM Minsoo 東京大学, 医科学研究所, 特任准教授 (50466835)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | エフェクター / 病原細菌 / 阻害剤 |
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| Research Abstract |
Many pathogenic bacteria, including Shigella, enteropathogenic Escherichia coli (EPEC), and enterohemorrhagic E.coli (EHEC), are associated with diarrheal diseases in young children in developing countries. Although these pathogens are a significant health threat in the developing world, many Japanese people have suffered from O157 infection. However, no effective vaccines have yet been developed. Multi-drug resistant bacteria are increasing problem. Therefore, we aim to develop new therapeutic tools to counteract the progression of these diseases.
To develop therapeutic tools against Shigella infection, we have analyzed the role of OspE during Shigella infection. ospE family genes are highly conserved among many enteropathogenic bacteria, including Shigella, O157, Citrobacter rodentium, and Salmonella, suggesting that OspE plays a general role in bacterial infection. We show here that OspE homologs play a key role in the establishment of during other pathogenic bacteria infection.
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Research Products
(14 results)
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[Journal Article] The Shigella OspC3 effector inhibits Cspase-4, antagonizes inflammatory cell death, and promotes epithelial infection2013
Author(s)
Kobayashi T, Ogawa M, Sanada T, Mimuro H, Kim M, Ashida H, Akakura R, Yoshida M, Kawalec M, Reichhart J-M, Mizushima T, Sasakawa C
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Journal Title
Cell Host Microbe
Volume: 13(5)
Pages: 570-83
DOI
Peer Reviewed
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[Journal Article] The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response2012
Author(s)
Sanada T, Kim M, Mimuro H, Suzuki M, Ogawa M, Oyama A, Ashida H, Kobayashi T, Koyama T, Nagai S, Shibata Y, Ghoda J, Inoue J-I, Mizushima T, Sasakawa C
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Journal Title
Nature
Volume: 483(7391)
Pages: 623-626
DOI
Peer Reviewed
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