2013 Fiscal Year Final Research Report
Analyzing Differentiation Programs and Population Regulation of Airway Epithelial Cells.
| Project/Area Number |
23689044
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Institute of Physical and Chemical Research (2012-2013)
National Institute of Genetics (2011) |
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Principal Investigator |
MORIMOTO Mitsuru 独立行政法人理化学研究所, 発生・再生総合科学研究センター, チームリーダー (70544344)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 発生学 / Notchシグナル / 呼吸器 |
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| Research Abstract |
In this project, we tried to decipher the principal mechanism of lung organogenesis by investigating cell differentiation programs and population balance regulations among airway epithelial cells. We determined that Notch2 promotes Clara cell differentiation by suppressing the ciliated cell program, and Notch1, 2, 3 cooperate in size regulation of neuroendocrine cell clusters. We further identified a novel cell population SPNC cell and proposed an idea that these SPNC cells regulate the size of the NEC clusters. On the other hand, transcriptome analysis for primary culture cells of tracheal epithelium revealed the differentiation program of ciliated cells from the basal cell type progenitors.
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