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2013 Fiscal Year Final Research Report

Effects of A2A-receptor antagonists on PD models via autophagy regulation.

Research Project

  • PDF
Project/Area Number 23689046
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Neurology
Research InstitutionJuntendo University

Principal Investigator

SAIKI Shinji  順天堂大学, 医学部, 准教授 (00339996)

Project Period (FY) 2011-04-01 – 2014-03-31
Keywords脳神経疾患
Research Abstract

Considering caffeine preventive effects on Parkinson's disease, we examined effects of caffeine analogues on PD cellular models via autophagic regulation using cellular models.
HeLa cells treated with a caffeine analogue have shown characteristics of autophagic inhibition via mTOR independent pathway, especially via cAMP. Also, one of them induced cell death in some cell lines but not in others. Taken together, some caffeine analogues might be potential candidates for anti-cancer agents.

  • Research Products

    (18 results)

All 2014 2013 2012 2011 Other

All Journal Article (10 results) Presentation (4 results) Book (1 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results) (of which Overseas: 1 results)

  • [Journal Article] p150^<glued>-associated disorders are caused by activation of intrinsic apoptotic pathway2014

    • Author(s)
      Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N
    • Journal Title

      PLOS ONE

      Volume: 9 Pages: e94645

  • [Journal Article] ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons2013

    • Author(s)
      Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R
    • Journal Title

      F EBS Lett

      Volume: 587 Pages: 1316-25

  • [Journal Article] Molecular pathogenesis of Parkinson disease : update2012

    • Author(s)
      Saiki S, Sato S, Hattori N
    • Journal Title

      J Neurol Neurosurg Psychiat

      Volume: 83 Pages: 430-6

  • [Journal Article] Mutations in the novel protein PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions2012

    • Author(s)
      Lee HY, Huang Y, Bruneau N, Roll P, Roberson EDO, Hermann M, Quinn E, Maas J, Edwards R, Ashizawa T, Baykan B, Bhatia K, Bressman S, Bruno MK, Brunt ER, Caraballo R, Echenne B, Fejerman N, Frucht S, Gurnett CA, Hirsch E, Houlden H, Jankovic J, Lee WL, Lynch DR, Mohamed S, Müller U, Nespeca MP, Renner D, Rochette J, Rudolf G, Saiki S, Soong BW, Swoboda KJ, Tucker S, Wood N, Hanna M, Bowcock A, Szepetowski P, Fu YH, Ptáček LJ
    • Journal Title

      Cell Reports

      Volume: 1 Pages: 2-12

  • [Journal Article] Genetic mutations and functions of PINK12011

    • Author(s)
      Kawajiri S, Saiki S, Sato S, Hattori N
    • Journal Title

      Trends Pharmacol Sci

      Volume: 32 Pages: 573-80

  • [Journal Article] DJ-1 associates with synaptic membranes2011

    • Author(s)
      Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 43 Pages: 651-62

  • [Journal Article] Lysosomal positioning coordinates cellular nutrient responses2011

    • Author(s)
      Korolchuk V, Saiki S, Lichtenberg M, Siddiqi F, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, O'Kane CJ, Deretic V and Rubinsztein DC
    • Journal Title

      Nat Cell Biol

      Volume: 13 Pages: 453-60

  • [Journal Article] Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition2011

    • Author(s)
      Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Kei-Ichi Ishikawa, Sato S, Imoto M, Hattori N
    • Journal Title

      Autophagy

      Volume: 7 Pages: 176-87

  • [Journal Article] Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects2011

    • Author(s)
      Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N
    • Journal Title

      Neurobiol Dis

      Volume: 41 Pages: 111-8

  • [Journal Article] Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease

    • Author(s)
      Fujimaki T, Saiki S, Tashiro E, Yamada D, Kitagawa M, Hattori N, Imoto M
    • Journal Title

      PLOS ONE

      Volume: (in press)

  • [Presentation] パーキンソン病と慢性炎症2014

    • Author(s)
      斉木臣二
    • Organizer
      第55回日本神経学会総会
    • Place of Presentation
      福岡国際会議場等福岡県
    • Year and Date
      20140521-24
  • [Presentation] オートファジーを標的としたパーキンソン病治療について2013

    • Author(s)
      斉木臣二
    • Organizer
      文部科学省科学研究費補助金新学術領域オートファジーの集学的研究シンポジウム・オートファジー研究会
    • Place of Presentation
      ヤマハリゾート嬬恋静岡県
    • Year and Date
      20131219-21
  • [Presentation] パーキンソン病病態とオートファジーの関連について2013

    • Author(s)
      斉木臣二
    • Organizer
      文部科学省科学研究費補助金新学術領域細胞内ロジスティクス・シンポジウム
    • Place of Presentation
      淡路夢舞台国際会議場兵庫県
    • Year and Date
      20130917-18
  • [Presentation] パーキンソン病の臨床と創薬-オートファジーとの関連を中心に-2013

    • Author(s)
      斉木臣二
    • Organizer
      第33回ゲノム創薬フォーラム
    • Place of Presentation
      東京大学医科学研究所東京都
    • Year and Date
      2013-07-25
  • [Book] Neuroacanthocytosis. In : Jankovic J, Tolosa E, eds. Parkinson's disease and movement disorders. 6th ed. Philadelphia, PA : Lippincott Williams & Wilkins2014

    • Author(s)
      Saiki S
    • Publisher
      (in press)
  • [Remarks] 所属教室ホームページ(順天堂大学脳神経内科)

    • URL

      http://www.juntendo-neurology.com/

  • [Remarks] 研究グループ紹介ページ

    • URL

      http://www.juntendo-neurology.com/pdf/kenkyu-saeki-furuya.pdf

  • [Patent(Industrial Property Rights)] パーキンソン病予防治療剤2013

    • Inventor(s)
      服部信孝、斉木臣二、井本正哉、藤 巻貴宏
    • Industrial Property Rights Holder
      学校法人順天堂
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2013-091903
    • Filing Date
      2013-04-25
    • Overseas

URL: 

Published: 2015-07-16  

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