2012 Fiscal Year Final Research Report
Genetic prediction of Th1 and Th17 cells activity in rheumatoid arthritis
| Project/Area Number |
23689051
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
KOCHI Yuta 独立行政法人理化学研究所, 自己免疫疾患研究チーム, 上級研究員 (60415156)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 関節リウマチ / 遺伝学 / Th1 細胞 / Th17 細胞 |
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| Research Abstract |
This study aimed to establish a model to predict sub-phenotypes in rheumatoid arthritis (RA) by using genetic polymorphisms, with a special focus on Th1- and Th17-cell activity. We quantified IFN-γ and IL-17A levels in the sera of RA patients (n=836). In addition, we genotyped polymorphisms in HLA-DRB1 and Th1/Th17 related genes. By using the genotypes and clinical information, we successfully predicted the status of IFN-γ and IL-17A with a logistic regression model (AUC in the ROC curve =0.887).
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