2013 Fiscal Year Final Research Report
Organ Engineering by Decellularized Scaffold for Transplant and Regenerative Therapy
| Project/Area Number |
23689059
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Keio University |
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Principal Investigator |
YAGI HIROSHI 慶應義塾大学, 医学部, 助教 (20327547)
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| Research Collaborator |
SOTO-GUTIERREZ A University of Pittsburgh, USA, Department of Pathology, Assistant Professor
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 幹細胞 / 臓器再生 / 再生医療 / 組織工学 |
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| Research Abstract |
Recent technology in stem cell engineering has raised new possibilities for the study of complex physiological processes in vitro, as well as the potential to fabricate entire organs for transplantation. After the huge progress in vitro using human-induced pluripotent stem cells which can differentiate relatively functional somatic cells, we should go for the next stage to investigate clinical applications of those cells using feasible animal models. Therefore, we have been developed a new technology using acellular three-dimensional scaffolds to generate transplantable whole liver which can be recellularized with appropriate cell types. It can retain all the necessary cues of tissue regeneration with efficient blood supply by suturing vascular access in vivo. For the clinical application, it should be applied to preclinical experimental large animal models. We believe that this technology may help to open new insight into organ regeneration as well as drug metabolism and toxicity.
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