2013 Fiscal Year Final Research Report
Corneal regeneration using epithelial, stromal, and endothelial precursor cells based on epigenetical control.
| Project/Area Number |
23689072
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Tokyo Women's Medical University (2012-2013)
The University of Tokyo (2011) |
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Principal Investigator |
MIMURA Tatsuya 東京女子医科大学, 医学部, 講師 (70463867)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 眼発生・再生医学 / エピジェネティクス / 角膜再生 |
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| Research Abstract |
We examined cellular aging and epigenetical alteration in corneal cells. We obtaiined corneal cells from endothelium, stoma, and epithelum of various aged donor corneas. Additionally, we obtained progenitor cells from each corneal cell layer by sphere-forming assay. By comparing the methylation among donor age, we found the ratio of methylation was higher in the cell from oleder donor cornea compared with younger donor conreas.
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Research Products
(73 results)
