2013 Fiscal Year Final Research Report
Establishment of therapeutic strategies to comprehensively control inflammation and bone destruction in arthritis
| Project/Area Number |
23689075
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (A)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | The University of Tokyo (2012-2013)
Tokyo Medical and Dental University (2011) |
|---|
Principal Investigator |
OKAMOTO Kazuo 東京大学, 医学(系)研究科(研究院), 助教 (00436643)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Keywords | 骨代謝 / 関節リウマチ / 破骨細胞 / 骨芽細胞 / Th17細胞 |
|---|
| Research Abstract |
The pathogenesis of bone destruction associated with chronic inflammation such as rheumatoid arthritis relied on two phases; abnormal immune responses and dysregulation of bone system. I've found that the transcription regulatory factor IkappaBzeta regulates Th17 development and is expressed in several bone cells. Thus, in this study, I attempted to determine the potential of IkappaBzeta as a therapeutic target for the treatment of inflammation-associated bone destruction, using genetically modified mice. Furthermore, I tried to identify a novel target cell/ factor that regulates both inflammation and bone destruction in arthritis. This study may provide the molecular basis for a new therapeutic strategy to block not only Th17-mediated inflammation but also osteoclastic bone destruction.
|
