2013 Fiscal Year Final Research Report
The roles of GABA on development and function of taste bud cells
| Project/Area Number |
23689076
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Functional basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
YOSHIDA Ryusuke 九州大学, 歯学研究科(研究院), 講師 (60380705)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 味細胞 / GABA / 遺伝子改変マウス / 味覚 / 発達 / Cl-濃度 |
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| Research Abstract |
This study has demonstrated that (1) GABA may not have a pivotal role in development of taste buds or taste cells and in innervation of gustatory nerve fibers to taste buds, (2) GABA may be released from a subset of taste cells, possibly Type III cells, by depolarization of these cells, (3) intracellular Cl- concentration in taste cells may be very high therefore GABA would induce excitatory responses in these taste cells. These results suggest that GABA may play some roles in modulation of taste sensitivities in taste buds.
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