2012 Fiscal Year Final Research Report
Statistical Analysis of Gene Expression Mechanism with Hierarchical Stochastic Model
| Project/Area Number |
23700263
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Sensitivity informatics/Soft computing
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体生命情報学 / 遺伝子 / 生物物理 |
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| Research Abstract |
In the present project, I investigated effects of temporally inhomogeneous noise on gene regulatory systems by using statistical methods and computational simulations. In order to perform the analysis, I developed an analytical approach and applied it to several biological models such as a bistable switch and a ratchet model. The developed method can calculate many statistical properties of systems driven by the temporally inhomogeneous noise. I also studied effects of structural inhomogeneity on the performance of genetic oscillators and showed that the existence of the period mismatch in a pair of coupled oscillators enhances entrainability, i.e. the ability to respond to external periodic stimuli.
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