Exact estimation of hazards under the several bias in medical research

2012 Fiscal Year Final Research Report

• Project/Area Number: 23700335
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Statistical science
• Research Institution: Kyoto University
• Principal Investigator: YOSHIMURA Kenichi 京都大学, 医学研究科, 助教 (30415517)
• Project Period (FY): 2011 – 2012

Research Abstract

A new estimation method of exact hazard parameter using weighted permutation was developed. This method is applicable to the situation with restrictions and bias that we frequently face in medical research, and it has a much broader range of application such as the analysis of individualized medicine, and data of randomized clinical trial using dynamic treatment allocation.

Research Products

• [Journal Article] Statistical issues and recommendations for noninferiority trials in oncology: a systematic review (2012)
  • Author(s): Tanaka S, Kinjo Y, Kataoka Y, Yoshimura K, Teramukai S
  • Journal Title: Clin Cancer Res Volume: 18 Pages: 1837-47
• [Journal Article] A combination of SCC-antigen, CEA, and CA19-9 predicts positive pelvic lymph nodes and parametrial involvement in early-stage squamous cell carcinoma of the uterine cervix. (2012)
  • Author(s): Ikeda S, Yoshimura K, Onda T, Kasamatsu T, Kato T, Ishikawa M, Sasajima Y, Tsuda H
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 38 Pages: 1260-1265
• [Journal Article] Risk of cancer in patients with autoimmune pancreatitis (2012)
  • Author(s): Shiokawa M, Kodama Y, Yoshimura K, Kawanami C, Mimura J, Yamashita Y, Asada M, Kikuyama M, Okabe Y, Inokuma T, Ohana M, Kokuryu H, Takeda K, Tsuji Y, Minami R, Sakuma Y, Kuriyama K, Ota Y, Tanabe W, Maruno T, Kurita A, Sawai Y, Uza N, Wata
  • Journal Title: Am J Gastroenterology Volume: (in press)
• [Journal Article] Optimal schedule of adjuvant chemotherapy with S-1 for stage III colon cancer: study protocol for a randomized controlled trial (2012)
  • Author(s): Yoshimura K, Uehara K, Tojima Y, Kawai S, Mokuno Y, Maeda A, Kyokane T, Kobayashi S, Yoshioka Y, Nagino M
  • Journal Title: Trials Volume: (in press)
• [Presentation] Expand Your Thinking Lecture - Biostatistics toward better communication between clinicians andbiostatisticians. (2012)
  • Author(s): Yoshimura K
  • Organizer: 5th Asia Pacific Lung Cancer Conference & 3rd International Thymic Malignancy Interest Group Annual Meeting
  • Year and Date: 20120000
• [Presentation] An issue in interpretation of results of clinical trials with survival endpoint when Cox model assumption does not necessarily hold in personalized medicine era (2011)
  • Author(s): Yoshimura K
  • Organizer: 3rd Worldwide Innovative Networking Symposium
  • Year and Date: 20110000
• [Presentation] Is median survival time difference a good measure of effectiveness in individualized medicine era? (2011)
  • Author(s): Yoshimura K, Teramukai S, Yamazaki K, Ohe Y
  • Organizer: Annual Meeting of American Society of Clinical Oncology
  • Year and Date: 20110000
• [Book] 誰も教えてくれなかった癌臨床試験の正しい解釈 (2011)
  • Author(s): 里見清一, 吉村健一
  • Publisher: 中外医学社