2012 Fiscal Year Final Research Report
Elucidation of modularity in transcriptional regulatory networks
| Project/Area Number |
23700352
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Toho University (2012)
Future University-Hakodate (2011) |
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Principal Investigator |
JOSE Nacher 東邦大学, 理学部, 准教授 (60452984)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転写調節ネットワーク / ncRNA / モジュール性 / ネットワーク解析 |
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| Research Abstract |
In this research, we investigate and compare the community structure of the network defined by functional interactions between non-coding RNAs (ncRNAs) and proteins related bio-macrolecules (PRMs) and the transcriptional regulatory network. Our findings show that the distributions of community sizes followed a scaling-law revealing a complex structure. In addition, the k-clique sub-graphs and overlaps show that the identified communities of the ncRNA molecules could potentially be associated with certain functions. Finally, we also derived mathematically the equations that predict projected network structure using only bipartite network information.
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