2012 Fiscal Year Final Research Report
Improvement of predictions of transcription factor binding sites using sequence dependent deformability of DNA
| Project/Area Number |
23700354
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Japan Atomic Energy Agency |
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Principal Investigator |
SUNAMI Tomoko 独立行政法人日本原子力研究開発機構, 量子ビーム応用研究部門, 研究職 (50554648)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 転写因子 / 蛋白質・DNA 相互作用 |
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| Research Abstract |
Deformation of DNA and transcription factors upon complex formation makes prediction of transcription factor binding sites difficult. In this study, we analyzed conformational changes of proteins in DNA interfaces. Our results showed that fragments of proteins to be DNA interfaces have intrinsic flexibility and are composed of amino acids that have high flexibility and DNA binding capability.
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