2012 Fiscal Year Final Research Report
Development of high accurate method for parameter estimation by the combination of numerical optimization and symbolic computation
| Project/Area Number |
23700358
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 生体生命システム情報学 |
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| Research Abstract |
We proposed highly accurate parameter estimation method based on time-series data, by introducing constraints equations among estimated parameters derived rationally by symbolic computing technique to numerical optimization method. The performance of our proposed method of parameter accuracy is demonstrated by some representative model in biology, especially negative feed-back model which yields oscillations. The highly accurate parameter estimation method for dynamical systems we proposed will be the basis of systemically identification, analysis, control, and design of biological phenomena.
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