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2013 Fiscal Year Final Research Report

Computational understanding of the mechanism of motor ataxia

Research Project

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Project/Area Number 23700360
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Bioinformatics/Life informatics
Research InstitutionNTT Communication Science Laboratories (2013)
Advanced Telecommunications Research Institute International (2011-2012)

Principal Investigator

IZAWA Jun  日本電信電話株式会社NTTコミュニケーション科学基礎研究所, 人間情報研究部, リサーチスペシャリスト (20582349)

Project Period (FY) 2011 – 2013
Keywords運動学習 / 運動制御 / 小脳 / 発達障害 / 計算理論
Research Abstract

The aim of this research is to understand the computational mechanism of how the damage of the brain generates motor deficits using the recently established computational framework of motor learning which is based on stochastic optimization theory. We proposed a motor adaptation system as a combination of optimal state estimator and optimal control mechanism and discussed a consistency between the propose model and previously discussed behavioral data. To confirm this idea, a new paradigm of a behavioral experiment was developed. We confirmed that the representation of internal model in the brain is not deterministic rather than stochastic. Then, the learning experiment with the cerebellar ataxia showed that updating sensory estimation was impaired whereas updating motor commands were preserved. This suggests that the cerebellum is responsible for forward model.

  • Research Products

    (11 results)

All 2013 2012 2011 Other

All Journal Article (4 results) Presentation (7 results)

  • [Journal Article] Cerebellar contributions to reach adaptation and learning sensory consequences of action2012

    • Author(s)
      Izawa J, Criscimagna-Hemminger SE, and Shadmehr R
    • Journal Title

      The Journal of Neuroscience

      Volume: 32(12) Pages: 4230-4239

  • [Journal Article] Motor learning relies on integrated sensory inputs in ADHD, but over-selectively on proprioception in Autism spectrum conditions2012

    • Author(s)
      Izawa J, Pekny SE, Marko MK, Haswell CC, Shadmehr R, and Mostofsky SH
    • Journal Title

      Autism Research

      Volume: 5 Pages: 124-136

  • [Journal Article] Stimulation of the human motor cortex alters generalization patterns of motor learning2011

    • Author(s)
      Orban de Xivry J, Marko MK, Pekny SE, Pastor D, Izawa J, Celnik P, and Shadmehr R
    • Journal Title

      The Journal of Neuroscience

      Volume: 31(19) Pages: 7102-7110

  • [Journal Article] The influence of uncertain force environment on reshaping trial-to-trial motor

    • Author(s)
      Izawa J, Yoshioka T, Osu R
    • Journal Title

      NeruroReport

      Volume: (accepted,印刷中)

  • [Presentation] Mechanisms for Generating Intermittency during manual tracking task, pp.559-5562013

    • Author(s)
      Asano T, Izawa J, Sakaguchi Y
    • Organizer
      Advances in Cognitive Neurodynamics (III), Proceedings of the Third International Conference on Cognitive Neurodynamics . 2011, ed.Yamaguchi,Yoko, Springer
    • Year and Date
      20130000
  • [Presentation] 6th International IEEE/EMBS Conference on Neural Engineering (IEEE NER)2013

    • Author(s)
      Ozawa T, Aihara T, Fujiwara Y, Otaka Y, Nambu I, Osu R, Izawa J, Wada Y
    • Organizer
      Detecting event-related motor activity using functional near-infrared spectroscopy, pp1529-1532
    • Year and Date
      20130000
  • [Presentation] Clamping errors selectively accentuated a cost-driven update of motor memory2013

    • Author(s)
      Izawa J, Yoshioka T, Osu R, Gomi H
    • Organizer
      Society for Neuroscience Meeting (SfN), 78.27/UU21
    • Year and Date
      20130000
  • [Presentation] Analysis of key factors on ERD production for BCI neuro-robotic rehabilitation, pp.240-2452012

    • Author(s)
      Takata Y, Saeki M, Izawa J, Takeda K, Otaka Y, Ito K, Kondo T
    • Organizer
      Proceedings of the IEEE RAS and EMBC International Conference on Biomedical Robotics and Biomechatronics(IEEE RAS EMBS)
    • Year and Date
      20120000
  • [Presentation] Analysis of extrinsic and intrinsic factors affecting event related desynchronization production, pp.4619-46222012

    • Author(s)
      Takata Y, Kondo T, Saeki M , Izawa J, Takeda K, Otaka Y, Ito K
    • Organizer
      2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society (IEEE EMBC)
    • Year and Date
      20120000
  • [Presentation] Internal model uncertainty reshapes trial-to-trial variability of motor commands2012

    • Author(s)
      Izawa J, Yoshioka T, and Osu R
    • Organizer
      Society for Neuroscience Annual Meeting (SfN) 88.15
    • Place of Presentation
      New Orleans, LA
    • Year and Date
      20120000
  • [Presentation] A role of cerebellum in maximizing rewards during visuomotor adaptation task"2011

    • Author(s)
      Izawa J, Criscimagna-Hemminger SE, and Shadmehr R
    • Organizer
      Society for Neuroscience Annual Meeting(SfN) , 836.3
    • Place of Presentation
      San Diego, CA
    • Year and Date
      20110000

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Published: 2015-06-25  

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