2012 Fiscal Year Final Research Report
Molecular mechanisms of target recognition and subcellular specificity in developing nervous system
| Project/Area Number |
23700364
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
SUTO Fumikazu 独立行政法人国立精神・神経医療研究センター, 神経研究所 微細構造研究部, 室長 (40345848)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 神経科学 / 発生・再生 / 神経発生 / 分子 / 神経回路 / 軸索誘導 / プレキシン / セマフォリン |
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| Research Abstract |
The amygdaloid complex is a principal component of the limbic system with important roles in emotion and fear memory. During development, axons of distinct amygdaloid nuclei project to different parts of the bed nucleus of the stria terminalis (BNST). However, it remains largely unknown how these connections are formed during development. Here, we examined the role of axon guidance molecule semaphorins and their receptor plexins in the formation of the amygdala-BNST network, and found that Sema6A/plexin-A4 signaling regulates the precise connectivity between the distinct amygdala projection neurons and their targets in the BNST.
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