2012 Fiscal Year Final Research Report
Phosphatidylethanolamine as an organizing molecule for neurite extension
| Project/Area Number |
23700365
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neuroscience in general
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Research Collaborator |
KANAHO Yasunori 筑波大学, 医学医療系, 教授 (00214437)
SUZUKI Atsushi 筑波大学, 大学院人間総合科学研究科, 博士課程学生
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| Project Period (FY) |
2011 – 2012
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| Keywords | 発生 / 発達 / 再生神経科学 |
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| Research Abstract |
We have examined whether and how phosphatidylethanolamine, a phospholipid consisting of the plasma membrane, is involved in neuronal morphogenesis. Our results indicated that the intramembranous movement (flip-flop movement) of phosphatidylethanolamine, which is induced by a type IV ATPase, controls neurite morphogenesis by organizing actin cytoskeleton in growth cones through the regulation of small G protein Cdc42.
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[Journal Article] NMDA receptor-mediated PIP5K activation to produce PI(4,5)P2 is essential for AMPA receptor endocytosis during LTD2012
Author(s)
Unoki Takamitsu, Shinji Matsuda, Wataru Kakegawa, Ngo Thai Bich Van, Kazuhisa Kohda, Atsushi Suzuki, Yuji Funakoshi, Hiroshi Hasegawa, Michisuke Yuzaki, Yasunori Kanaho
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Journal Title
Neuron
Volume: 73巻
Pages: 135-148
DOI
Peer Reviewed
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